5ux4: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 5ux4 is ON HOLD until Paper Publication~~

==Crystal Structure of Rat Cathepsin D with (5S)-3-(5,6-dihydro-2H-pyran-3-yl)-1-fluoro- 7-(2-fluoropyridin-3-yl)spiro[chromeno[2,3- c]pyridine-5,4'-[1,3]oxazol]-2'-amine==

~~Authors: Sickmier, A.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5ux4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UX4 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UX4 FirstGlance].

~~Description:~~ Crystal Structure of Rat Cathepsin D with (5S)-3-(5,6-dihydro-2H-pyran-3-yl)-1-fluoro-7-(2-fluoropyridin-3-yl)spiro[chromeno[2,3-c]pyridine-5,4'-[1,3]oxazol]-2'-amine

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=3UT:(5S)-3-(5,6-DIHYDRO-2H-PYRAN-3-YL)-1-FLUORO-7-(2-FLUOROPYRIDIN-3-YL)SPIRO[CHROMENO[2,3-C]PYRIDINE-5,4-[1,3]OXAZOL]-2-AMINE'>3UT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Cathepsin_D Cathepsin D], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.5 3.4.23.5] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ux4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ux4 OCA], [http://pdbe.org/5ux4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ux4 RCSB], [http://www.ebi.ac.uk/pdbsum/5ux4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ux4 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/CATD_RAT CATD_RAT]] Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.[UniProtKB:P07339]

__TOC__

</StructureSection>

[[Category: Cathepsin D]]

[[Category: Sickmier, A]]

[[Category: Bace1]]

[[Category: Beta amyloid cleaving enzyme]]

[[Category: Cathepsin d]]

[[Category: Hydrolase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5ux4 is ON HOLD  until Paper Publication
+==Crystal Structure of Rat Cathepsin D with (5S)-3-(5,6-dihydro-2H-pyran-3-yl)-1-fluoro- 7-(2-fluoropyridin-3-yl)spiro[chromeno[2,3- c]pyridine-5,4'-[1,3]oxazol]-2'-amine==
+<StructureSection load='5ux4' size='340' side='right' caption='[[5ux4]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
-Authors: Sickmier, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ux4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UX4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UX4 FirstGlance]. <br>
-Description: Crystal Structure of Rat Cathepsin D with (5S)-3-(5,6-dihydro-2H-pyran-3-yl)-1-fluoro-7-(2-fluoropyridin-3-yl)spiro[chromeno[2,3-c]pyridine-5,4'-[1,3]oxazol]-2'-amine
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UT:(5S)-3-(5,6-DIHYDRO-2H-PYRAN-3-YL)-1-FLUORO-7-(2-FLUOROPYRIDIN-3-YL)SPIRO[CHROMENO[2,3-C]PYRIDINE-5,4-[1,3]OXAZOL]-2-AMINE'>3UT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_D Cathepsin D], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.5 3.4.23.5] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ux4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ux4 OCA], [http://pdbe.org/5ux4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ux4 RCSB], [http://www.ebi.ac.uk/pdbsum/5ux4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ux4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CATD_RAT CATD_RAT]] Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.[UniProtKB:P07339]
+__TOC__
+</StructureSection>
+[[Category: Cathepsin D]]
 [[Category: Sickmier, A]]
+[[Category: Bace1]]
+[[Category: Beta amyloid cleaving enzyme]]
+[[Category: Cathepsin d]]
+[[Category: Hydrolase]]