5v2n: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5v2n is ~~ON HOLD until Paper Publication~~

==Crystal Structure of APO Human SETD8==

~~Authors~~: ~~Skene~~, R.J.

== Structural highlights ==

<table><tr><td colspan='2'>[[5v2n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V2N FirstGlance]. <br>

~~Description: Crystal Structure of APO Human SETD8~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v2n OCA], [http://pdbe.org/5v2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v2n RCSB], [http://www.ebi.ac.uk/pdbsum/5v2n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v2n ProSAT]</span></td></tr>

[[Category: Skene, R.J]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/KMT5A_HUMAN KMT5A_HUMAN]] Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.<ref>PMID:12086618</ref> <ref>PMID:12121615</ref> <ref>PMID:15200950</ref> <ref>PMID:15933069</ref> <ref>PMID:15933070</ref> <ref>PMID:16517599</ref> <ref>PMID:17707234</ref> <ref>PMID:23478445</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Skene, R J]]

[[Category: Methyl transferase]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5v2n is ON HOLD  until Paper Publication
+==Crystal Structure of APO Human SETD8==
+<StructureSection load='5v2n' size='340' side='right' caption='[[5v2n]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-Authors: Skene, R.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5v2n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V2N FirstGlance]. <br>
-Description: Crystal Structure of APO Human SETD8
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v2n OCA], [http://pdbe.org/5v2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v2n RCSB], [http://www.ebi.ac.uk/pdbsum/5v2n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v2n ProSAT]</span></td></tr>
-[[Category: Skene, R.J]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KMT5A_HUMAN KMT5A_HUMAN]] Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.<ref>PMID:12086618</ref> <ref>PMID:12121615</ref> <ref>PMID:15200950</ref> <ref>PMID:15933069</ref> <ref>PMID:15933070</ref> <ref>PMID:16517599</ref> <ref>PMID:17707234</ref> <ref>PMID:23478445</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Skene, R J]]
+[[Category: Methyl transferase]]
+[[Category: Transferase]]