5vbp: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5vbp is ~~ON HOLD~~ ~~until Paper Publication~~

==CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH RO3280==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5vbp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VBP OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VBP FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=79C:4-[(9-CYCLOPENTYL-7,7-DIFLUORO-5-METHYL-6-OXO-6,7,8,9-TETRAHYDRO-5H-PYRIMIDO[4,5-B][1,4]DIAZEPIN-2-YL)AMINO]-3-METHOXY-N-(1-METHYLPIPERIDIN-4-YL)BENZAMIDE'>79C</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5vbo|5vbo]], [[5vbq|5vbq]], [[5vbr|5vbr]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vbp OCA], [http://pdbe.org/5vbp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vbp RCSB], [http://www.ebi.ac.uk/pdbsum/5vbp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vbp ProSAT]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>

== Function ==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

== References ==

__TOC__

</StructureSection>

[[Category: EMBER, S W]]

[[Category: SCHONBRUNN, E]]

[[Category: ZHU, J Y]]

[[Category: Bromodomain]]

[[Category: Cap]]

[[Category: Hunk1]]

[[Category: Inhibitor]]

[[Category: Mcap]]

[[Category: Mitotic chromosome associated protein]]

[[Category: Protein binding-inhibitor complex]]

[[Category: Transcription-inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5vbp is ON HOLD  until Paper Publication
+==CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH RO3280==
+<StructureSection load='5vbp' size='340' side='right' caption='[[5vbp]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5vbp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VBP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VBP FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=79C:4-[(9-CYCLOPENTYL-7,7-DIFLUORO-5-METHYL-6-OXO-6,7,8,9-TETRAHYDRO-5H-PYRIMIDO[4,5-B][1,4]DIAZEPIN-2-YL)AMINO]-3-METHOXY-N-(1-METHYLPIPERIDIN-4-YL)BENZAMIDE'>79C</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vbo|5vbo]], [[5vbq|5vbq]], [[5vbr|5vbr]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vbp OCA], [http://pdbe.org/5vbp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vbp RCSB], [http://www.ebi.ac.uk/pdbsum/5vbp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vbp ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: EMBER, S W]]
+[[Category: SCHONBRUNN, E]]
+[[Category: ZHU, J Y]]
+[[Category: Bromodomain]]
+[[Category: Cap]]
+[[Category: Hunk1]]
+[[Category: Inhibitor]]
+[[Category: Mcap]]
+[[Category: Mitotic chromosome associated protein]]
+[[Category: Protein binding-inhibitor complex]]
+[[Category: Transcription-inhibitor complex]]