5vbr: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5vbr is ~~ON HOLD~~ ~~until Paper Publication~~

==CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRDT IN COMPLEX WITH Volasertib==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5vbr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VBR OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VBR FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IBI:N-{TRANS-4-[4-(CYCLOPROPYLMETHYL)PIPERAZIN-1-YL]CYCLOHEXYL}-4-{[(7R)-7-ETHYL-5-METHYL-8-(1-METHYLETHYL)-6-OXO-5,6,7,8-TETRAHYDROPTERIDIN-2-YL]AMINO}-3-METHOXYBENZAMIDE'>IBI</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5vbo|5vbo]], [[5vbp|5vbp]], [[5vbq|5vbq]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vbr OCA], [http://pdbe.org/5vbr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vbr RCSB], [http://www.ebi.ac.uk/pdbsum/5vbr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vbr ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/BRDT_HUMAN BRDT_HUMAN]] Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin.<ref>PMID:9367677</ref> <ref>PMID:15647849</ref> <ref>PMID:22901802</ref>

== References ==

__TOC__

</StructureSection>

[[Category: EMBER, S W]]

[[Category: SCHONBRUNN, E]]

[[Category: ZHU, J Y]]

[[Category: Bromodomain]]

[[Category: Cap]]

[[Category: Hunk1]]

[[Category: Inhibitor]]

[[Category: Mcap]]

[[Category: Mitotic chromosome associated protein]]

[[Category: Protein binding-inhibitor complex]]

[[Category: Transcription-inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5vbr is ON HOLD  until Paper Publication
+==CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRDT IN COMPLEX WITH Volasertib==
+<StructureSection load='5vbr' size='340' side='right' caption='[[5vbr]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5vbr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VBR FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IBI:N-{TRANS-4-[4-(CYCLOPROPYLMETHYL)PIPERAZIN-1-YL]CYCLOHEXYL}-4-{[(7R)-7-ETHYL-5-METHYL-8-(1-METHYLETHYL)-6-OXO-5,6,7,8-TETRAHYDROPTERIDIN-2-YL]AMINO}-3-METHOXYBENZAMIDE'>IBI</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vbo|5vbo]], [[5vbp|5vbp]], [[5vbq|5vbq]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vbr OCA], [http://pdbe.org/5vbr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vbr RCSB], [http://www.ebi.ac.uk/pdbsum/5vbr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vbr ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRDT_HUMAN BRDT_HUMAN]] Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin.<ref>PMID:9367677</ref> <ref>PMID:15647849</ref> <ref>PMID:22901802</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: EMBER, S W]]
+[[Category: SCHONBRUNN, E]]
+[[Category: ZHU, J Y]]
+[[Category: Bromodomain]]
+[[Category: Cap]]
+[[Category: Hunk1]]
+[[Category: Inhibitor]]
+[[Category: Mcap]]
+[[Category: Mitotic chromosome associated protein]]
+[[Category: Protein binding-inhibitor complex]]
+[[Category: Transcription-inhibitor complex]]