5nnd: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5nnd is ~~ON HOLD until Paper Publication~~

==Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H3K9ac/K14ac)==

~~Authors~~: ~~Filippakopoulos~~, P.~~, Picaud, S~~., ~~Pike, A~~.C.W., ~~von Delft~~, F.~~, Arrowsmith, C~~.H., ~~Edwards, A~~.M., ~~Bountra, C~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[5nnd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NND OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NND FirstGlance].

~~Description~~: ~~Crystal Structure of the first bromodomain of human~~ BRD4 in ~~complex~~ with a ~~diacetylated histone 4 peptide (H3K9ac~~/~~K14ac)~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>

[[Category: ~~Pike~~, A.C.W]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nnd OCA], [http://pdbe.org/5nnd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nnd RCSB], [http://www.ebi.ac.uk/pdbsum/5nnd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nnd ProSAT]</td></tr>

[[Category: ~~Arrowsmith~~, C.H]]

</table>

[[Category: ~~Von~~ Delft, F]]

== Disease ==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>

== Function ==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

== References ==

__TOC__

</StructureSection>

[[Category: Arrowsmith, C H]]

[[Category: Bountra, C]]

[[Category: Delft, F von]]

[[Category: Edwards, A M]]

[[Category: Filippakopoulos, P]]

[[Category: Picaud, S]]

[[Category: ~~Filippakopoulos~~, P]]

[[Category: Pike, A C.W]]

[[Category: ~~Edwards, A.M~~]]

[[Category: Bromodomain]]

[[Category: ~~Bountra, C~~]]

[[Category: Complex]]

[[Category: Transcription]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5nnd is ON HOLD  until Paper Publication
+==Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H3K9ac/K14ac)==
+<StructureSection load='5nnd' size='340' side='right' caption='[[5nnd]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
-Authors: Filippakopoulos, P., Picaud, S., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5nnd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NND OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NND FirstGlance]. <br>
-Description: Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H3K9ac/K14ac)
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-[[Category: Pike, A.C.W]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nnd OCA], [http://pdbe.org/5nnd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nnd RCSB], [http://www.ebi.ac.uk/pdbsum/5nnd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nnd ProSAT]</span></td></tr>
-[[Category: Arrowsmith, C.H]]
+</table>
-[[Category: Von Delft, F]]
+== Disease ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
+[[Category: Delft, F von]]
+[[Category: Edwards, A M]]
+[[Category: Filippakopoulos, P]]
 [[Category: Picaud, S]]
-[[Category: Filippakopoulos, P]]
+[[Category: Pike, A C.W]]
-[[Category: Edwards, A.M]]
+[[Category: Bromodomain]]
-[[Category: Bountra, C]]
+[[Category: Complex]]
+[[Category: Transcription]]