5vmb: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5vmb is ~~ON HOLD~~

==Crystal structure of a glycine hydroxymethyltransferase from Acinetobacter baumannii==

~~Authors~~: ~~Seattle Structural Genomics Center for Infectious Disease~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5vmb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VMB OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VMB FirstGlance].

~~Description~~: ~~Crystal structure~~ of a ~~glycine~~ hydroxymethyltransferase ~~from Acinetobacter baumannii~~

</td></tr><tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vmb OCA], [http://pdbe.org/5vmb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vmb RCSB], [http://www.ebi.ac.uk/pdbsum/5vmb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vmb ProSAT]</td></tr>

[[Category: ~~Seattle Structural Genomics Center For Infectious Disease~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/V5VBJ2_ACIBA V5VBJ2_ACIBA]] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051]

__TOC__

</StructureSection>

[[Category: Glycine hydroxymethyltransferase]]

[[Category: Structural genomic]]

[[Category: Essentiallity screen]]

[[Category: Niaid]]

[[Category: Protein production]]

[[Category: Serine production]]

[[Category: Ssgcid]]

[[Category: Thf]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5vmb is ON HOLD
+==Crystal structure of a glycine hydroxymethyltransferase from Acinetobacter baumannii==
+<StructureSection load='5vmb' size='340' side='right' caption='[[5vmb]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-Authors: Seattle Structural Genomics Center for Infectious Disease
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5vmb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VMB FirstGlance]. <br>
-Description: Crystal structure of a glycine hydroxymethyltransferase from Acinetobacter baumannii
+</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vmb OCA], [http://pdbe.org/5vmb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vmb RCSB], [http://www.ebi.ac.uk/pdbsum/5vmb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vmb ProSAT]</span></td></tr>
-[[Category: Seattle Structural Genomics Center For Infectious Disease]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/V5VBJ2_ACIBA V5VBJ2_ACIBA]] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051]
+__TOC__
+</StructureSection>
+[[Category: Glycine hydroxymethyltransferase]]
+[[Category: Structural genomic]]
+[[Category: Essentiallity screen]]
+[[Category: Niaid]]
+[[Category: Protein production]]
+[[Category: Serine production]]
+[[Category: Ssgcid]]
+[[Category: Thf]]
+[[Category: Transferase]]