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==Mutant Endotoxin TeNT==
==Mutant Endotoxin TeNT==
<StructureSection load='4j1l' size='340' side='right' caption='[[4j1l]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='4j1l' size='340' side='right'caption='[[4j1l]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4j1l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clote Clote]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J1L FirstGlance]. <br>
<table><tr><td colspan='2'>[[4j1l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_tetani_E88 Clostridium tetani E88]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J1L FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tetX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=212717 CLOTE])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j1l OCA], [https://pdbe.org/4j1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j1l RCSB], [https://www.ebi.ac.uk/pdbsum/4j1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j1l ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j1l OCA], [http://pdbe.org/4j1l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j1l RCSB], [http://www.ebi.ac.uk/pdbsum/4j1l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j1l ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE]] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.  
[https://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Clote]]
[[Category: Clostridium tetani E88]]
[[Category: Tentoxilysin]]
[[Category: Large Structures]]
[[Category: Chen, S]]
[[Category: Chen S]]
[[Category: Guo, J]]
[[Category: Guo J]]
[[Category: Pan, X]]
[[Category: Pan X]]
[[Category: Zhao, Y]]
[[Category: Zhao Y]]
[[Category: Endotoxin]]
[[Category: Toxin]]

Revision as of 21:24, 16 November 2022

Mutant Endotoxin TeNT

4j1l, resolution 2.60Å

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