5giy: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5giy is ~~ON HOLD until Jun 25 2018~~

==HSA-Palmitic acid-[RuCl5(ind)]2-==

~~Authors~~: ~~Yang~~, F., ~~Wang~~, T.

== Structural highlights ==

<table><tr><td colspan='2'>[[5giy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GIY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GIY FirstGlance]. <br>

~~Description~~: ~~HSA-Palmitic acid-~~[~~RuCl5~~(~~ind~~)]2-

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7GE:pentakis(chloranyl)-(1~{H}-indazol-2-ium-2-yl)ruthenium(1-)'>7GE</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5giy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5giy OCA], [http://pdbe.org/5giy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5giy RCSB], [http://www.ebi.ac.uk/pdbsum/5giy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5giy ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>

== Function ==

[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Wang, T]]

[[Category: Yang, F]]

[[Category: ~~Wang, T~~]]

[[Category: Anticancer activity]]

[[Category: Drug delivery system]]

[[Category: Human serum albumin]]

[[Category: Interactions of protein-ligand]]

[[Category: Peptide binding protein]]

[[Category: Ruthenium-based drug]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5giy is ON HOLD  until Jun 25 2018
+==HSA-Palmitic acid-[RuCl5(ind)]2-==
+<StructureSection load='5giy' size='340' side='right' caption='[[5giy]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
-Authors: Yang, F., Wang, T.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5giy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GIY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GIY FirstGlance]. <br>
-Description: HSA-Palmitic acid-[RuCl5(ind)]2-
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7GE:pentakis(chloranyl)-(1~{H}-indazol-2-ium-2-yl)ruthenium(1-)'>7GE</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5giy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5giy OCA], [http://pdbe.org/5giy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5giy RCSB], [http://www.ebi.ac.uk/pdbsum/5giy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5giy ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Wang, T]]
 [[Category: Yang, F]]
-[[Category: Wang, T]]
+[[Category: Anticancer activity]]
+[[Category: Drug delivery system]]
+[[Category: Human serum albumin]]
+[[Category: Interactions of protein-ligand]]
+[[Category: Peptide binding protein]]
+[[Category: Ruthenium-based drug]]