5nyh: Difference between revisions
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==Crystal Structure of Hsp90-alpha N-Domain in complex with Indazole derivative== | |||
<StructureSection load='5nyh' size='340' side='right' caption='[[5nyh]], [[Resolution|resolution]] 1.65Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5nyh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NYH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NYH FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9EK:~{N}-methyl-~{N}-(4-morpholin-4-ylphenyl)-6-oxidanyl-3-pyrrolidin-1-ylcarbonyl-2~{H}-indazole-5-carboxamide'>9EK</scene></td></tr> | |||
[[ | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5nyd|5nyd]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nyh OCA], [http://pdbe.org/5nyh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nyh RCSB], [http://www.ebi.ac.uk/pdbsum/5nyh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nyh ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Amaral, M]] | [[Category: Amaral, M]] | ||
[[Category: Chaperone]] | |||
Revision as of 05:36, 18 April 2018
Crystal Structure of Hsp90-alpha N-Domain in complex with Indazole derivative
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