5q0m: Difference between revisions

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'''Unreleased structure'''


The entry 5q0m is ON HOLD
==Ligand binding to FARNESOID-X-RECEPTOR==
 
<StructureSection load='5q0m' size='340' side='right' caption='[[5q0m]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
Authors: Benz, J., Burger, D., Joseph, C., Rudolph, M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5q0m]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Q0M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Q0M FirstGlance]. <br>
Description: Ligand binding to FARNESOID-X-RECEPTOR
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9L1:5-{[(3beta,5beta,14beta,17alpha)-3-hydroxy-24-oxocholan-24-yl]amino}benzene-1,3-dicarboxylic+acid'>9L1</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5q0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5q0m OCA], [http://pdbe.org/5q0m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5q0m RCSB], [http://www.ebi.ac.uk/pdbsum/5q0m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5q0m ProSAT]</span></td></tr>
[[Category: Joseph, C]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Benz, J]]
[[Category: Benz, J]]
[[Category: Rudolph, M]]
[[Category: Burger, D]]
[[Category: Burger, D]]
[[Category: Burley, S K]]
[[Category: Joseph, C]]
[[Category: Kuhn, B]]
[[Category: Rudolph, M G]]
[[Category: Ruf, A]]
[[Category: Shao, C]]
[[Category: Thoma, R]]
[[Category: Yang, H]]
[[Category: D3r]]
[[Category: Docking]]
[[Category: Fxr]]
[[Category: Transcription]]
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