5vh2: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5vh2 is ~~ON HOLD~~ ~~until Paper Publication~~

==Crystal Structure of Mouse Cadherin-23 EC12-13 with Engineered Mutation S1339D==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5vh2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VH2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VH2 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vh2 OCA], [http://pdbe.org/5vh2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vh2 RCSB], [http://www.ebi.ac.uk/pdbsum/5vh2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vh2 ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Defects in Cdh23 are the cause of waltzer (v) phenotype. Waltzer mice are characterized by deafness and vestibular dysfunction due to degeneration of the neuroepithelium within the inner ear.

== Function ==

[[http://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:11138008</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Jaiganesh, A]]

[[Category: Sotomayor, M]]

[[Category: Termine, D J]]

[[Category: Adhesion]]

[[Category: Calcium-binding protein]]

[[Category: Cell adhesion]]

[[Category: Hearing]]

[[Category: Mechanotransduction]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5vh2 is ON HOLD  until Paper Publication
+==Crystal Structure of Mouse Cadherin-23 EC12-13 with Engineered Mutation S1339D==
+<StructureSection load='5vh2' size='340' side='right' caption='[[5vh2]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5vh2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VH2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VH2 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vh2 OCA], [http://pdbe.org/5vh2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vh2 RCSB], [http://www.ebi.ac.uk/pdbsum/5vh2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vh2 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Defects in Cdh23 are the cause of waltzer (v) phenotype. Waltzer mice are characterized by deafness and vestibular dysfunction due to degeneration of the neuroepithelium within the inner ear.
+== Function ==
+[[http://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:11138008</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Jaiganesh, A]]
+[[Category: Sotomayor, M]]
+[[Category: Termine, D J]]
+[[Category: Adhesion]]
+[[Category: Calcium-binding protein]]
+[[Category: Cell adhesion]]
+[[Category: Hearing]]
+[[Category: Mechanotransduction]]