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| <StructureSection load='1aik' size='340' side='right' caption='Core structure of gp41 from the HIV envelope glycoprotein, [[1aik]].' scene=''> | | <StructureSection load='1aik' size='340' side='right' caption='Core structure of acetylated gp41 from the HIV envelope glycoprotein, [[1aik]].' scene=''> |
| == Function == | | == Function == |
| '''Gp41''' is a subunit of the envelope protein of retrovirus<ref>PMID:9630213</ref>. Gp41 is a transmembrane protein and contains several sites which are involved in the infection of the host cells. Gp160 is the cleavable precursor of Gp41 and Gp120. For more details see [[Hiv env proteins]]. | | '''Gp41''' is a subunit of the envelope protein of retrovirus<ref>PMID:9630213</ref>. Gp41 is a transmembrane protein and contains several sites which are involved in the infection of the host cells. Gp160 is the cleavable precursor of Gp41 and Gp120. For more details see [[Hiv env proteins]]. |
Revision as of 21:15, 19 October 2017
| Function
Gp41 is a subunit of the envelope protein of retrovirus[1]. Gp41 is a transmembrane protein and contains several sites which are involved in the infection of the host cells. Gp160 is the cleavable precursor of Gp41 and Gp120. For more details see Hiv env proteins.
Relevance
Fusion inhibitory drugs which bind to Gp41 prevent the attachment of the HIV-1 virus to the cell[2].
- ↑ Chan DC, Kim PS. HIV entry and its inhibition. Cell. 1998 May 29;93(5):681-4. PMID:9630213
- ↑ Root MJ, Steger HK. HIV-1 gp41 as a target for viral entry inhibition. Curr Pharm Des. 2004;10(15):1805-25. PMID:15180542
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3D Structures of Gp41
Updated on 19-October-2017
{"openlevels":0}
- Gp41 from HIV-1
- Hiv env proteins – Gp41
- 1env, 3k9a – Gp41 (mutant)
- 1szt – Gp41 thermostable domain
- 3cp1, 3cyo – Gp41 thermostable domain (mutant)
- 1df4, 1df5, 1qr8, 1qr9, 1dlb, 1jpx – Gp41 core
- 1f23, 1k33, 1k34, 1i5x, 1i5y, 2ot5 – Gp41 core (mutant)
- 5ka6, 5ka5 – Gp41 transmembrane (mutant)
- 2z2t, 2zzo, 3aha, 3vie, 2r3c, 2r5b, 2r5d, 3l36, 3l37, 3vgy, 3vh7, 3vtp, 3vu5, 3vu6, 5h0n – Gp41 N-heptad repeat + Gp41 fusion inhibitor peptide
- 2zfc – Gp41 N-peptide
- 4i2l – Gp41 N-peptide (mutant)
- 3u91 – Gp41 N-terminal
- 4hlr – Gp41 N-terminal (mutant)
- 5v8l, 5v8m, 5uty, 5utf, 5um8, 5jsa, 5js9, 5i8h, 5d9q, 5cjx, 5c7k – Gp41 + Gp120 + antibody
- 5u1f, 5thr – Gp41 + Gp120 + antibody + CD4
- 5fyk, 5fyj, 4nco – Gp41 + Gp120 (mutant) + antibody
- 5hm1 – Gp41 + llama antibody
- 3o3x – arGp41 - artificial
- 4dzu – arGp41 + 3-α
- 4dzv – arGp41 + 4-α/β
- Gp41 from Simian Immunodeficiency Virus
References
proteopedia link