GTP-binding protein: Difference between revisions
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== Disease == | == Disease == | ||
Mutations in heterotrimeric G protein α subunit were identified in endocrine tumors and in McCune-Albright syndrome<ref>PMID:11720871</ref>. | Mutations in heterotrimeric G protein α subunit were identified in endocrine tumors and in McCune-Albright syndrome<ref>PMID:11720871</ref>. | ||
== Relevance == | |||
Rho-related small GTP-binding protein is inhibited by the antifungal drug cancidas. See [[Cancidas]]. | |||
== Structural highlights == | == Structural highlights == | ||
''E. coli'' small GTPase ERA binds GDP in a cavity formed by <scene name='46/463251/Cv/3'>3 highly conserved regions G1, G4, G5</scene><ref>PMID:19706445</ref>. <scene name='46/463251/Cv/6'>GDP binding site</scene>. Water molecules shown as red spheres. | ''E. coli'' small GTPase ERA binds GDP in a cavity formed by <scene name='46/463251/Cv/3'>3 highly conserved regions G1, G4, G5</scene><ref>PMID:19706445</ref>. <scene name='46/463251/Cv/6'>GDP binding site</scene>. Water molecules shown as red spheres. | ||
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**[[2rex]] – hRho6 + plexin-B1<br /> | **[[2rex]] – hRho6 + plexin-B1<br /> | ||
**[[1cc0]] – hRhoA + GDP-dissociation inhibitor + GDP<br /> | **[[1cc0]] – hRhoA + GDP-dissociation inhibitor + GDP<br /> | ||
**[[3a58]] – yRho1 (mutant) + exocyst complex component Sec3<br /> | **[[3a58]] – yRho1 (mutant) + exocyst complex component Sec3 + cancidas<br /> | ||
**[[1gzs]] – Cdc42 + guanine nucleotide exchange factor – ''Salmonella typhimurium''<br /> | **[[1gzs]] – Cdc42 + guanine nucleotide exchange factor – ''Salmonella typhimurium''<br /> | ||
**[[2kb0]] - hCdc42 (mutant)<br /> | **[[2kb0]] - hCdc42 (mutant)<br /> | ||
