TRAIL: Difference between revisions
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<StructureSection load='1d0g' size='340' side='right' caption='Human TRAIL trimer residues 114-281 (grey, light green, yellow) complex with death receptor-5 extracellular domain (dark blue, dark green, olive), Zn+2 (grey) and Cl-1 (green) ions, [[1d0g]]' scene='' pspeed='8'> | <StructureSection load='1d0g' size='340' side='right' caption='Human TRAIL trimer residues 114-281 (grey, light green, yellow) complex with death receptor-5 extracellular domain (dark blue, dark green, olive), Zn+2 (grey) and Cl-1 (green) ions, [[1d0g]]' scene='' pspeed='8'> | ||
== Function == | == Function == | ||
'''TRAIL (TNF-related apoptosis-inducing ligand)''' functions as a ligand in the process of apoptosis<ref>PMID:15987601</ref>. TRAIL binds to death receptors DR4, DR5, DcR1 and DcR2. For details see [[Molecular Playground/TRAIL]]. <scene name='48/480878/Cv/1'>TRAIL trimer residues complex with death receptor-5 extracellular domain</scene> ([[1d0g]]). <scene name='48/480878/Cv/2'>Zn+2 and Cl-1 bind to 3 same Cys residues from different subunits of TRAIL trimer</scene>. | '''TRAIL (TNF-related apoptosis-inducing ligand)''' or '''TNF ligand superfamily 10''' functions as a ligand in the process of apoptosis<ref>PMID:15987601</ref>. TRAIL binds to death receptors DR4, DR5, DcR1 and DcR2. For details see [[Molecular Playground/TRAIL]]. <scene name='48/480878/Cv/1'>TRAIL trimer residues complex with death receptor-5 extracellular domain</scene> ([[1d0g]]). <scene name='48/480878/Cv/2'>Zn+2 and Cl-1 bind to 3 same Cys residues from different subunits of TRAIL trimer</scene>. | ||
== Disease == | == Disease == | ||
TRAIL concentrations are reduced in rheumatoid | TRAIL concentrations are reduced in rheumatoid arthritis<ref>PMID:25962765</ref>. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of TRAIL == | == 3D Structures of TRAIL == | ||
[[1d0g]], [[1d4v]], [[1du3]] - hTRAIL | [[1d0g]], [[1d4v]], [[1du3]], [[5cir]] - hTRAIL extracellular domain + DR5 extracellular domain - human<br /> | ||
[[1dg6]] – hTRAIL jelly-roll domain<br /> | [[1dg6]] – hTRAIL jelly-roll domain<br /> | ||
[[1d2q]] - hTRAIL extracellular domain | [[1d2q]] - hTRAIL extracellular domain<br /> | ||
[[4n90]] - hTRAIL extracellular domain + DR5 extracellular domain + antibody<br /> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 22:05, 10 October 2017
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3D Structures of TRAIL
Molecular Playground/TRAIL, 1d0g, 1du3, 5cir - hTRAIL extracellular domain + DR5 extracellular domain - human
1dg6 – hTRAIL jelly-roll domain
1d2q - hTRAIL extracellular domain
4n90 - hTRAIL extracellular domain + DR5 extracellular domain + antibody
