1vyb: Difference between revisions
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'''ENDONUCLEASE DOMAIN OF HUMAN LINE1 ORF2P''' | '''ENDONUCLEASE DOMAIN OF HUMAN LINE1 ORF2P''' | ||
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[[Category: Repanas, K.]] | [[Category: Repanas, K.]] | ||
[[Category: Weichenrieder, O.]] | [[Category: Weichenrieder, O.]] | ||
[[Category: | [[Category: Ape-1 type]] | ||
[[Category: | [[Category: Endonuclease]] | ||
[[Category: | [[Category: Retrotransposition]] | ||
[[Category: | [[Category: Retrotransposon]] | ||
[[Category: | [[Category: Rna-directed dna polymerase]] | ||
[[Category: | [[Category: Transferase]] | ||
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Revision as of 09:54, 3 May 2008
ENDONUCLEASE DOMAIN OF HUMAN LINE1 ORF2P
Overview
The human L1 endonuclease (L1-EN) is encoded by the non-LTR retrotransposon LINE-1 (L1). L1 is responsible for more than 1.5 million retrotransposition events in the history of the human genome, contributing more than a quarter to human genomic DNA (L1 and Alu elements). L1-EN is related to the well-understood human DNA repair endonuclease APE1, and its nicking specificity is a major determinant for retrotransposon integration site selection. The crystal structure of human L1 endonuclease is the first of a retrotransposon-encoded protein and a prototype for retrotransposon-encoded endonucleases involved in target-primed reverse transcription. Structure-based endonuclease alignments reveal a conserved threonine in addition to previously identified invariant residues and suggest that DNA recognition proceeds via the accommodation of an extrahelical nucleotide within a pocket of the enzyme. The present analysis will help to refine phylogenetic and functional relationships among metal-dependent phosphohydrolases and provides a basis for manipulating non-LTR retrotransposon integration site selection.
About this Structure
1VYB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the targeting endonuclease of the human LINE-1 retrotransposon., Weichenrieder O, Repanas K, Perrakis A, Structure. 2004 Jun;12(6):975-86. PMID:15274918 Page seeded by OCA on Sat May 3 12:54:34 2008
