1w51: Difference between revisions

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[[Image:1w51.gif|left|200px]]
[[Image:1w51.gif|left|200px]]


{{Structure
<!--
|PDB= 1w51 |SIZE=350|CAPTION= <scene name='initialview01'>1w51</scene>, resolution 2.55&Aring;
The line below this paragraph, containing "STRUCTURE_1w51", creates the "Structure Box" on the page.
|SITE= <scene name='pdbsite=AC1:L01+Binding+Site+For+Chain+A'>AC1</scene>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
|LIGAND= <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=L01:3-[({(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}AMINO)(HYDROXY)METHYL]-N,N-DIPROPYLBENZAMIDE'>L01</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span>
or leave the SCENE parameter empty for the default display.
|GENE=  
-->
|DOMAIN=
{{STRUCTURE_1w51| PDB=1w51  | SCENE= }}  
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w51 OCA], [http://www.ebi.ac.uk/pdbsum/1w51 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w51 RCSB]</span>
}}


'''BACE (BETA SECRETASE) IN COMPLEX WITH A NANOMOLAR NON-PEPTIDIC INHIBITOR'''
'''BACE (BETA SECRETASE) IN COMPLEX WITH A NANOMOLAR NON-PEPTIDIC INHIBITOR'''
Line 31: Line 28:
[[Category: Vuillard, L.]]
[[Category: Vuillard, L.]]
[[Category: Yon, J.]]
[[Category: Yon, J.]]
[[Category: alternative splicing]]
[[Category: Alternative splicing]]
[[Category: alzheimer's disease]]
[[Category: Alzheimer's disease]]
[[Category: aspartic protease]]
[[Category: Aspartic protease]]
[[Category: aspartyl protease]]
[[Category: Aspartyl protease]]
[[Category: base]]
[[Category: Base]]
[[Category: beta-secretase]]
[[Category: Beta-secretase]]
[[Category: glycoprotein]]
[[Category: Glycoprotein]]
[[Category: hydrolase]]
[[Category: Hydrolase]]
[[Category: memapsin 2]]
[[Category: Memapsin 2]]
[[Category: signal]]
[[Category: Signal]]
[[Category: transmembrane]]
[[Category: Transmembrane]]
[[Category: zymogen]]
[[Category: Zymogen]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 13:10:10 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:31:18 2008''

Revision as of 10:10, 3 May 2008

File:1w51.gif

Template:STRUCTURE 1w51

BACE (BETA SECRETASE) IN COMPLEX WITH A NANOMOLAR NON-PEPTIDIC INHIBITOR


Overview

Human BACE, also known as beta-secretase, shows promise as a potential therapeutic target for Alzheimer's disease. We determined the apo structure of BACE to 1.75 A, and a structure of a hydroxyethylamine inhibitor complex derived by soaking. These show significant active-site movements compared to previously described BACE structures. Additionally, the structures reveal two pockets that could be targeted by structure-based drug design.

About this Structure

1W51 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Apo and inhibitor complex structures of BACE (beta-secretase)., Patel S, Vuillard L, Cleasby A, Murray CW, Yon J, J Mol Biol. 2004 Oct 15;343(2):407-16. PMID:15451669 Page seeded by OCA on Sat May 3 13:10:10 2008

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