1wp0: Difference between revisions
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'''Human SCO1''' | '''Human SCO1''' | ||
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[[Category: Williams, J C.]] | [[Category: Williams, J C.]] | ||
[[Category: Yang, H.]] | [[Category: Yang, H.]] | ||
[[Category: | [[Category: Cu-binding protein]] | ||
[[Category: | [[Category: Mitochondrial assembly factor]] | ||
[[Category: | [[Category: Redox]] | ||
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Revision as of 10:58, 3 May 2008
Human SCO1
Overview
Human SCO1 and SCO2 are copper-binding proteins involved in the assembly of mitochondrial cytochrome c oxidase (COX). We have determined the crystal structure of the conserved, intermembrane space core portion of apo-hSCO1 to 2.8 A. It is similar to redox active proteins, including thioredoxins (Trx) and peroxiredoxins (Prx), with putative copper-binding ligands located at the same positions as the conserved catalytic residues in Trx and Prx. SCO1 does not have disulfide isomerization or peroxidase activity, but both hSCO1 and a sco1 null in yeast show extreme sensitivity to hydrogen peroxide. Of the six missense mutations in SCO1 and SCO2 associated with fatal mitochondrial disorders, one lies in a highly conserved exposed surface away from the copper-binding region, suggesting that this region is involved in protein-protein interactions. These data suggests that SCO functions not as a COX copper chaperone, but rather as a mitochondrial redox signaling molecule.
About this Structure
1WP0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of human SCO1: implications for redox signaling by a mitochondrial cytochrome c oxidase "assembly" protein., Williams JC, Sue C, Banting GS, Yang H, Glerum DM, Hendrickson WA, Schon EA, J Biol Chem. 2005 Apr 15;280(15):15202-11. Epub 2005 Jan 19. PMID:15659396 Page seeded by OCA on Sat May 3 13:58:01 2008
