5lo1: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5lo1 is ~~ON HOLD until Paper Publication~~

==HSP90 WITH indazole derivative==

~~Authors~~: ~~Graedler~~, U., ~~Amaral~~, M., ~~Schuetz~~, D.

== Structural highlights ==

<table><tr><td colspan='2'>[[5lo1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LO1 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LO1 FirstGlance].

~~Description~~: ~~HSP90 WITH indazole derivative~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=70L:1-[2-Amino-4-(1,3-dihydro-isoindole-2-carbonyl)-quinazolin-6-yl]-cyclobutanecarboxylic+acid+ethylamide'>70L</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4eeh|4eeh]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lo1 OCA], [http://pdbe.org/5lo1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lo1 RCSB], [http://www.ebi.ac.uk/pdbsum/5lo1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lo1 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Amaral, M]]

[[Category: Graedler, U]]

[[Category: Schuetz, D]]

[[Category: ~~Graedler, U]]~~

[[Category: Chaperone]]

~~[[Category: Amaral, M~~]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5lo1 is ON HOLD  until Paper Publication
+==HSP90 WITH indazole derivative==
+<StructureSection load='5lo1' size='340' side='right' caption='[[5lo1]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-Authors: Graedler, U., Amaral, M., Schuetz, D.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5lo1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LO1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LO1 FirstGlance]. <br>
-Description: HSP90 WITH indazole derivative
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=70L:1-[2-Amino-4-(1,3-dihydro-isoindole-2-carbonyl)-quinazolin-6-yl]-cyclobutanecarboxylic+acid+ethylamide'>70L</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4eeh|4eeh]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lo1 OCA], [http://pdbe.org/5lo1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lo1 RCSB], [http://www.ebi.ac.uk/pdbsum/5lo1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lo1 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Amaral, M]]
+[[Category: Graedler, U]]
 [[Category: Schuetz, D]]
-[[Category: Graedler, U]]
+[[Category: Chaperone]]
-[[Category: Amaral, M]]