5o9h: Difference between revisions

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'''Unreleased structure'''


The entry 5o9h is ON HOLD
==Crystal structure of thermostabilised human C5a anaphylatoxin chemotactic receptor 1 (C5aR) in complex with NDT9513727==
 
<StructureSection load='5o9h' size='340' side='right' caption='[[5o9h]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5o9h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O9H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O9H FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9P2:1-(1,3-benzodioxol-5-yl)-~{N}-(1,3-benzodioxol-5-ylmethyl)-~{N}-[(3-butyl-2,5-diphenyl-imidazol-4-yl)methyl]methanamine'>9P2</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o9h OCA], [http://pdbe.org/5o9h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o9h RCSB], [http://www.ebi.ac.uk/pdbsum/5o9h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o9h ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/C5AR1_HUMAN C5AR1_HUMAN]] Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).<ref>PMID:10636859</ref> <ref>PMID:15153520</ref> <ref>PMID:1847994</ref> <ref>PMID:7622471</ref> <ref>PMID:8182049</ref> <ref>PMID:9553099</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bottegoni, G]]
[[Category: Brown, J]]
[[Category: Cansfield, J]]
[[Category: Cooke, R M]]
[[Category: Dore, A S]]
[[Category: Jazayeri, A]]
[[Category: Koglin, M]]
[[Category: Marshall, F H]]
[[Category: Rappas, M]]
[[Category: Robertson, N]]
[[Category: Gpcr]]
[[Category: Membrane protein]]
[[Category: Signalling protein]]
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