5o9k: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "5o9k" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal structure of Murine Histmaine-Releasing Factor (HRF/TCTP)== | |||
<StructureSection load='5o9k' size='340' side='right' caption='[[5o9k]], [[Resolution|resolution]] 4.01Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5o9k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O9K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O9K FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o9k OCA], [http://pdbe.org/5o9k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o9k RCSB], [http://www.ebi.ac.uk/pdbsum/5o9k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o9k ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TCTP_MOUSE TCTP_MOUSE]] Involved in calcium binding and microtubule stabilization. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
In allergic disease, mast cell activation is conventionally triggered by allergen-mediated cross-linking of receptor-bound IgE on the cell surface. In addition to its diverse range of intracellular roles in apoptosis, cell proliferation and cancer, Histamine-Releasing Factor (HRF) also activates mast cells and basophils. A subset of IgE antibodies bind HRF through their Fab regions, and two IgE binding sites on HRF have been mapped. HRF can form dimers, and a disulphide-linked dimer is critical for activity. The current model for the activity of HRF in mast cell activation involves cross-linking of receptor-bound IgE by dimeric HRF, mediated by HRF/Fab interactions. HRF crystal and solution structures have provided little insight into either the formation of disulphide-linked HRF dimers or the ability of HRF to activate mast cells. We report the first crystal structure of murine HRF (mHRF) to 4.0A resolution, revealing a conserved fold. We also solved the structure of human HRF (hHRF) in two new crystal forms, one at the highest resolution (1.4A) yet reported. The high resolution hHRF structure reveals a disulphide-linked dimer, in which the two molecules are closely associated, and provides a model for the role of both human and murine HRF in mast cell activation. | |||
Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation.,Dore KA, Kashiwakura JI, McDonnell JM, Gould HJ, Kawakami T, Sutton BJ, Davies AM Mol Immunol. 2018 Jan;93:216-222. doi: 10.1016/j.molimm.2017.11.022. Epub 2017, Dec 5. PMID:29216544<ref>PMID:29216544</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 5o9k" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Davies, A M]] | |||
[[Category: Dore, K A]] | |||
[[Category: Gould, H J]] | |||
[[Category: Kashiwakura, J]] | |||
[[Category: Kawakami, T]] | |||
[[Category: McDonnell, J M]] | |||
[[Category: Sutton, B J]] | |||
[[Category: Allergy]] | |||
[[Category: Fortilin]] | |||
[[Category: Histamine releasing factor]] | |||
[[Category: Hrf]] | |||
[[Category: Immune system]] | |||
[[Category: Immunoglobulin e]] | |||
[[Category: P21]] | |||
[[Category: P23]] | |||
[[Category: Tctp]] | |||
Revision as of 06:12, 20 December 2017
Crystal structure of Murine Histmaine-Releasing Factor (HRF/TCTP)
| ||||||||||||
