5ocu: Difference between revisions

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'''Unreleased structure'''


The entry 5ocu is ON HOLD
==Molecular basis of human kinesin-8 function and inhibition==
 
<StructureSection load='5ocu' size='340' side='right' caption='[[5ocu]], [[Resolution|resolution]] 5.20&Aring;' scene=''>
Authors: Locke, J., Joseph, A.P., Topf, M., Moores, C.A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5ocu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ], [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OCU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OCU FirstGlance]. <br>
Description: Molecular basis of human kinesin-8 function and inhibition
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ogc|5ogc]], [[5oam|5oam]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ocu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ocu OCA], [http://pdbe.org/5ocu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ocu RCSB], [http://www.ebi.ac.uk/pdbsum/5ocu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ocu ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/KI18A_HUMAN KI18A_HUMAN]] Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression.<ref>PMID:17346968</ref> <ref>PMID:18267093</ref> <ref>PMID:18513970</ref> <ref>PMID:19625775</ref>  [[http://www.uniprot.org/uniprot/TBB_PIG TBB_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/F2Z4C1_BOVIN F2Z4C1_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.[RuleBase:RU000352][SAAS:SAAS00824325]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Sus scrofa]]
[[Category: Joseph, A P]]
[[Category: Locke, J]]
[[Category: Moores, C A]]
[[Category: Topf, M]]
[[Category: Topf, M]]
[[Category: Moores, C.A]]
[[Category: Cytoskeleton]]
[[Category: Locke, J]]
[[Category: Kinesin]]
[[Category: Joseph, A.P]]
[[Category: Motor protein]]
[[Category: Transport protein]]
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