5ou7: Difference between revisions
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The entry | ==Crystal structure of the Glycoprotein VI loop truncation mutant PAVS-PAPYKN== | ||
<StructureSection load='5ou7' size='340' side='right' caption='[[5ou7]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ou7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OU7 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PG6:1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE'>PG6</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ou7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ou7 OCA], [http://pdbe.org/5ou7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ou7 RCSB], [http://www.ebi.ac.uk/pdbsum/5ou7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ou7 ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/GPVI_HUMAN GPVI_HUMAN]] Bleeding diathesis due to glycoprotein VI deficiency. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/GPVI_HUMAN GPVI_HUMAN]] Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.<ref>PMID:10961879</ref> <ref>PMID:18955485</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Feitsma, L J]] | |||
[[Category: Huizinga, E G]] | |||
[[Category: Blood clotting]] | |||
[[Category: Collagen-binding]] | |||
[[Category: Glycoprotein]] | |||
[[Category: Gpvi]] | |||
[[Category: Platelet]] | |||
[[Category: Platelet activation]] | |||
Revision as of 09:59, 5 September 2018
Crystal structure of the Glycoprotein VI loop truncation mutant PAVS-PAPYKN
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