5ov2: Difference between revisions
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==2'F-ANA-G modified quadruplex with a flipped tetrad== | |||
<StructureSection load='5ov2' size='340' side='right' caption='[[5ov2]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ov2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OV2 FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GFL:2-AMINO-9-(2-DEOXY-2-FLUORO-5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-1,9-DIHYDRO-6H-PURIN-6-ONE'>GFL</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2lod|2lod]], [[5mcr|5mcr]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ov2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ov2 OCA], [http://pdbe.org/5ov2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ov2 RCSB], [http://www.ebi.ac.uk/pdbsum/5ov2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ov2 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
A G-quadruplex adopting a (3 + 1)-hybrid structure was substituted at its 5'-tetrad by 2'-deoxy-2'-fluoro-arabinoguanosine (FaraG) analogs. Incorporation of anti-favoring FaraG at syn-positions of the 5'-outer tetrad induced a reversal of the tetrad polarity without noticeably compromising the quadruplex stability. This conformational change is shown to be promoted by nonconventional C-H...F hydrogen bonds acting within the anti-FaraG residues. | |||
Nonconventional C-H...F Hydrogen Bonds Support a Tetrad Flip in Modified G-Quadruplexes.,Dickerhoff J, Weisz K J Phys Chem Lett. 2017 Oct 6:5148-5152. doi: 10.1021/acs.jpclett.7b02428. PMID:28976755<ref>PMID:28976755</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 5ov2" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dickerhoff, J]] | |||
[[Category: Weisz, K]] | |||
[[Category: 2'f-ana]] | |||
[[Category: Dna]] | |||
[[Category: G-quadruplex]] | |||
