5owm: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5owm is ~~ON HOLD~~

==Crystal structure of human BRD4(1) bromodomain in complex with UT48==

~~Authors~~: ~~Zhu~~, J., ~~Caflisch~~, A.

== Structural highlights ==

<table><tr><td colspan='2'>[[5owm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OWM FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of ~~human BRD4~~(1) ~~bromodomain in complex~~ with ~~UT48~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B0N:[3-[(3-methylbenzotriazol-5-yl)methyl]phenyl]methanol'>B0N</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5owm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5owm OCA], [http://pdbe.org/5owm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5owm RCSB], [http://www.ebi.ac.uk/pdbsum/5owm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5owm ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>

== Function ==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

== References ==

__TOC__

</StructureSection>

[[Category: Caflisch, A]]

[[Category: Zhu, J]]

[[Category: Dna binding protein]]

[[Category: Inhibitor]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5owm is ON HOLD
+==Crystal structure of human BRD4(1) bromodomain in complex with UT48==
+<StructureSection load='5owm' size='340' side='right' caption='[[5owm]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-Authors: Zhu, J., Caflisch, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5owm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OWM FirstGlance]. <br>
-Description: Crystal structure of human BRD4(1) bromodomain in complex with UT48
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B0N:[3-[(3-methylbenzotriazol-5-yl)methyl]phenyl]methanol'>B0N</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5owm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5owm OCA], [http://pdbe.org/5owm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5owm RCSB], [http://www.ebi.ac.uk/pdbsum/5owm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5owm ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Caflisch, A]]
 [[Category: Zhu, J]]
+[[Category: Dna binding protein]]
+[[Category: Inhibitor]]