5tyi: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5tyi is ~~ON HOLD~~ ~~until Paper Publication~~

==Grb7 SH2 with bicyclic peptide containing pY mimetic==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5tyi]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TYI OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TYI FirstGlance].

~~Description~~:

</td></tr><tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=48V:{[(2R)-2,3-DIAMINO-3-OXOPROPYL]SULFANYL}ACETIC+ACID'>48V</scene>, <scene name='pdbligand=99Y:'>99Y</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5u06|5u06]], [[5u1q|5u1q]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tyi OCA], [http://pdbe.org/5tyi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tyi RCSB], [http://www.ebi.ac.uk/pdbsum/5tyi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tyi ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/GRB7_HUMAN GRB7_HUMAN]] Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).<ref>PMID:10893408</ref> <ref>PMID:12021278</ref> <ref>PMID:12223469</ref> <ref>PMID:20622016</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Watson, G M]]

[[Category: Wilce, J A]]

[[Category: Wilce, M C.J]]

[[Category: Bicyclic]]

[[Category: Inhibitor]]

[[Category: Sh2]]

[[Category: Signaling protein-peptide complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5tyi is ON HOLD  until Paper Publication
+==Grb7 SH2 with bicyclic peptide containing pY mimetic==
+<StructureSection load='5tyi' size='340' side='right' caption='[[5tyi]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5tyi]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TYI FirstGlance]. <br>
-Description:
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=48V:{[(2R)-2,3-DIAMINO-3-OXOPROPYL]SULFANYL}ACETIC+ACID'>48V</scene>, <scene name='pdbligand=99Y:'>99Y</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5u06|5u06]], [[5u1q|5u1q]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tyi OCA], [http://pdbe.org/5tyi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tyi RCSB], [http://www.ebi.ac.uk/pdbsum/5tyi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tyi ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/GRB7_HUMAN GRB7_HUMAN]] Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).<ref>PMID:10893408</ref> <ref>PMID:12021278</ref> <ref>PMID:12223469</ref> <ref>PMID:20622016</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Watson, G M]]
+[[Category: Wilce, J A]]
+[[Category: Wilce, M C.J]]
+[[Category: Bicyclic]]
+[[Category: Inhibitor]]
+[[Category: Sh2]]
+[[Category: Signaling protein-peptide complex]]