5vki: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5vki is ~~ON HOLD until Paper Publication~~

==Crystal structure of P[19] rotavirus VP8* complexed with mucin core 2==

~~Authors~~: Xu, S., ~~Liu~~, Y., ~~Woodruff~~, A., ~~Zhong~~, W., ~~Jiang~~, X., ~~Kennedy, M~~.A.

== Structural highlights ==

<table><tr><td colspan='2'>[[5vki]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VKI OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VKI FirstGlance].

~~Description~~: ~~Crystal structure~~ of P[19] ~~rotavirus~~ VP8* ~~complexed with mucin core 2~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THR:THREONINE'>THR</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5vks|5vks]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vki OCA], [http://pdbe.org/5vki PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vki RCSB], [http://www.ebi.ac.uk/pdbsum/5vki PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vki ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/A7YCM0_9REOV A7YCM0_9REOV]] Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment.[SAAS:SAAS00846030] VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.[SAAS:SAAS00846016]

__TOC__

</StructureSection>

[[Category: Jiang, X]]

[[Category: Kennedy, M A]]

[[Category: Liu, Y]]

[[Category: Woodruff, A]]

[[Category: Xu, S]]

[[Category: Zhong, W]]

[[Category: ~~Jiang, X~~]]

[[Category: Complex]]

[[Category: ~~Xu, S~~]]

[[Category: Mucin core 2]]

[[Category: ~~Kennedy, M.A]]~~

[[Category: Viral protein]]

~~[[Category: Woodruff, A~~]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5vki is ON HOLD  until Paper Publication
+==Crystal structure of P[19] rotavirus VP8* complexed with mucin core 2==
+<StructureSection load='5vki' size='340' side='right' caption='[[5vki]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-Authors: Xu, S., Liu, Y., Woodruff, A., Zhong, W., Jiang, X., Kennedy, M.A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5vki]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VKI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VKI FirstGlance]. <br>
-Description: Crystal structure of P[19] rotavirus VP8* complexed with mucin core 2
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THR:THREONINE'>THR</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vks|5vks]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vki OCA], [http://pdbe.org/5vki PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vki RCSB], [http://www.ebi.ac.uk/pdbsum/5vki PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vki ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/A7YCM0_9REOV A7YCM0_9REOV]] Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment.[SAAS:SAAS00846030]  VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.[SAAS:SAAS00846016]
+__TOC__
+</StructureSection>
+[[Category: Jiang, X]]
+[[Category: Kennedy, M A]]
 [[Category: Liu, Y]]
+[[Category: Woodruff, A]]
+[[Category: Xu, S]]
 [[Category: Zhong, W]]
-[[Category: Jiang, X]]
+[[Category: Complex]]
-[[Category: Xu, S]]
+[[Category: Mucin core 2]]
-[[Category: Kennedy, M.A]]
+[[Category: Viral protein]]
-[[Category: Woodruff, A]]