5w4g: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5w4g is ~~ON HOLD until Paper Publication~~

==Importin binding to NLS peptide of DNA polymerase lambda==

~~Authors~~: ~~Pedersen~~, L.C., ~~London~~, R.E.

== Structural highlights ==

<table><tr><td colspan='2'>[[5w4g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W4G OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W4G FirstGlance].

~~Description~~: ~~Importin~~ binding to ~~NLS peptide~~ of ~~DNA polymerase lambda~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5w4e|5w4e]], [[5w4f|5w4f]]</td></tr>

[[Category: London, R.E]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w4g OCA], [http://pdbe.org/5w4g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w4g RCSB], [http://www.ebi.ac.uk/pdbsum/5w4g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w4g ProSAT]</td></tr>

[[Category: Pedersen, L.C]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE]] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [[http://www.uniprot.org/uniprot/DPOLL_HUMAN DPOLL_HUMAN]] Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.<ref>PMID:11457865</ref> <ref>PMID:15537631</ref>

== References ==

__TOC__

</StructureSection>

[[Category: London, R E]]

[[Category: Pedersen, L C]]

[[Category: Importin]]

[[Category: Nl]]

[[Category: Nuclear transport]]

[[Category: Polymerase lambda]]

[[Category: Protein binding]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5w4g is ON HOLD  until Paper Publication
+==Importin binding to NLS peptide of DNA polymerase lambda==
+<StructureSection load='5w4g' size='340' side='right' caption='[[5w4g]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
-Authors: Pedersen, L.C., London, R.E.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5w4g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W4G FirstGlance]. <br>
-Description: Importin binding to NLS peptide of DNA polymerase lambda
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5w4e|5w4e]], [[5w4f|5w4f]]</td></tr>
-[[Category: London, R.E]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w4g OCA], [http://pdbe.org/5w4g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w4g RCSB], [http://www.ebi.ac.uk/pdbsum/5w4g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w4g ProSAT]</span></td></tr>
-[[Category: Pedersen, L.C]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE]] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [[http://www.uniprot.org/uniprot/DPOLL_HUMAN DPOLL_HUMAN]] Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.<ref>PMID:11457865</ref> <ref>PMID:15537631</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: London, R E]]
+[[Category: Pedersen, L C]]
+[[Category: Importin]]
+[[Category: Nl]]
+[[Category: Nuclear transport]]
+[[Category: Polymerase lambda]]
+[[Category: Protein binding]]