5w5z: Difference between revisions
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==Crystal structure of BAXP168G in complex with an activating antibody at high resolution== | |||
<StructureSection load='5w5z' size='340' side='right' caption='[[5w5z]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5w5z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W5Z FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w5z OCA], [http://pdbe.org/5w5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w5z RCSB], [http://www.ebi.ac.uk/pdbsum/5w5z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w5z ProSAT]</span></td></tr> | ||
[[Category: Czabotar, P | </table> | ||
[[Category: | == Function == | ||
[[http://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN]] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Colman, P M]] | |||
[[Category: Czabotar, P E]] | |||
[[Category: Robin, A Y]] | |||
[[Category: Apoptosis]] | |||
[[Category: Bax activation]] | |||
[[Category: Fab]] | |||
[[Category: Unfolding]] | |||
Revision as of 05:27, 27 June 2018
Crystal structure of BAXP168G in complex with an activating antibody at high resolution
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