5wc9: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5wc9 is ~~ON HOLD until Paper Publication~~

==Human Pit-1 and 4xCATT DNA complex==

~~Authors~~: ~~Agarwal~~, S., ~~Cho~~, T.Y.

== Structural highlights ==

<table><tr><td colspan='2'>[[5wc9]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WC9 FirstGlance]. <br>

~~Description: Human Pit-1 and 4xCATT DNA complex~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wc9 OCA], [http://pdbe.org/5wc9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wc9 RCSB], [http://www.ebi.ac.uk/pdbsum/5wc9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wc9 ProSAT]</span></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

</table>

[[~~Category~~: ~~Cho, T~~.Y]]

== Disease ==

[[http://www.uniprot.org/uniprot/PIT1_HUMAN PIT1_HUMAN]] Hypothyroidism due to deficient transcription factors involved in pituitary development or function;Combined pituitary hormone deficiencies, genetic forms. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[[http://www.uniprot.org/uniprot/PIT1_HUMAN PIT1_HUMAN]] Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Specifically binds to the consensus sequence 5'-TAAAT-3'. Activates growth hormone and prolactin genes (PubMed:22010633, PubMed:26612202).<ref>PMID:22010633</ref> <ref>PMID:26612202</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Agarwal, S]]

[[Category: Cho, T Y]]

[[Category: Dna binding protein]]

[[Category: Dna-protein complex]]

[[Category: Transcription regulation]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5wc9 is ON HOLD  until Paper Publication
+==Human Pit-1 and 4xCATT DNA complex==
+<StructureSection load='5wc9' size='340' side='right' caption='[[5wc9]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
-Authors: Agarwal, S., Cho, T.Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5wc9]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WC9 FirstGlance]. <br>
-Description: Human Pit-1 and 4xCATT DNA complex
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wc9 OCA], [http://pdbe.org/5wc9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wc9 RCSB], [http://www.ebi.ac.uk/pdbsum/5wc9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wc9 ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Cho, T.Y]]
+== Disease ==
+[[http://www.uniprot.org/uniprot/PIT1_HUMAN PIT1_HUMAN]] Hypothyroidism due to deficient transcription factors involved in pituitary development or function;Combined pituitary hormone deficiencies, genetic forms. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/PIT1_HUMAN PIT1_HUMAN]] Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Specifically binds to the consensus sequence 5'-TAAAT-3'. Activates growth hormone and prolactin genes (PubMed:22010633, PubMed:26612202).<ref>PMID:22010633</ref> <ref>PMID:26612202</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Agarwal, S]]
+[[Category: Cho, T Y]]
+[[Category: Dna binding protein]]
+[[Category: Dna-protein complex]]
+[[Category: Transcription regulation]]