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'''Unreleased structure'''


The entry 5wer is ON HOLD  until Paper Publication
==Crystal Structure of TAPBPR and H2-Dd complex==
 
<StructureSection load='5wer' size='340' side='right' caption='[[5wer]], [[Resolution|resolution]] 3.41&Aring;' scene=''>
Authors: Jiang, J.S., Natarajan, K., Boyd, L.F., Margulies, D.H.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5wer]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WER OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WER FirstGlance]. <br>
Description: Crystal Structure of TAPBPR and H2-Dd complex
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5mes|5mes]]</td></tr>
[[Category: Margulies, D.H]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wer FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wer OCA], [http://pdbe.org/5wer PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wer RCSB], [http://www.ebi.ac.uk/pdbsum/5wer PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wer ProSAT]</span></td></tr>
[[Category: Jiang, J.S]]
</table>
[[Category: Boyd, L.F]]
== Disease ==
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>  Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref> 
== Function ==
[[http://www.uniprot.org/uniprot/HA12_MOUSE HA12_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Boyd, L F]]
[[Category: Jiang, J S]]
[[Category: Margulies, D H]]
[[Category: Natarajan, K]]
[[Category: Natarajan, K]]
[[Category: Antigen presentation]]
[[Category: Immune response]]
[[Category: Immune system]]
[[Category: Major histompatibility complex class i]]
[[Category: Mhc-i]]
[[Category: Peptide editing]]
[[Category: Peptide loading complex]]
[[Category: Plc]]
[[Category: Tapasin]]
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