5wi9: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5wi9 is ~~ON HOLD until Paper Publication~~

==Crystal structure of KL with an agonist Fab==

~~Authors~~: ~~Johnstone~~, S., ~~Min~~, X., ~~Wang~~, Z.

== Structural highlights ==

<table><tr><td colspan='2'>[[5wi9]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WI9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WI9 FirstGlance]. <br>

~~Description: Crystal structure of KL with an agonist Fab~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wi9 OCA], [http://pdbe.org/5wi9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wi9 RCSB], [http://www.ebi.ac.uk/pdbsum/5wi9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wi9 ProSAT]</span></td></tr>

~~[[Category: Wang, Z]]~~

</table>

== Function ==

[[http://www.uniprot.org/uniprot/KLOTB_HUMAN KLOTB_HUMAN]] Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).

__TOC__

</StructureSection>

[[Category: Johnstone, S]]

[[Category: Min, X]]

[[Category: Wang, Z]]

[[Category: Beta-klotho]]

[[Category: Fibroblast growth factor]]

[[Category: Scaffold protein]]

[[Category: Structural protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5wi9 is ON HOLD  until Paper Publication
+==Crystal structure of KL with an agonist Fab==
+<StructureSection load='5wi9' size='340' side='right' caption='[[5wi9]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-Authors: Johnstone, S., Min, X., Wang, Z.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5wi9]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WI9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WI9 FirstGlance]. <br>
-Description: Crystal structure of KL with an agonist Fab
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wi9 OCA], [http://pdbe.org/5wi9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wi9 RCSB], [http://www.ebi.ac.uk/pdbsum/5wi9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wi9 ProSAT]</span></td></tr>
-[[Category: Wang, Z]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KLOTB_HUMAN KLOTB_HUMAN]] Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).
+__TOC__
+</StructureSection>
 [[Category: Johnstone, S]]
 [[Category: Min, X]]
+[[Category: Wang, Z]]
+[[Category: Beta-klotho]]
+[[Category: Fibroblast growth factor]]
+[[Category: Scaffold protein]]
+[[Category: Structural protein]]