5wiu: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5wiu is ~~ON HOLD until Paper Publication~~

==Structure of the human D4 Dopamine receptor in complex with Nemonapride==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5wiu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WIU OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WIU FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=AQD:Nemonapride'>AQD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5wiv|5wiv]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wiu OCA], [http://pdbe.org/5wiu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wiu RCSB], [http://www.ebi.ac.uk/pdbsum/5wiu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wiu ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DRD4_HUMAN DRD4_HUMAN]] Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).

__TOC__

</StructureSection>

[[Category: Betz, R M]]

[[Category: Che, T]]

[[Category: Dror, R O]]

[[Category: Huang, X P]]

[[Category: Levit, A]]

[[Category: McCorvy, J D]]

[[Category: Roth, B L]]

[[Category: Shoichet, B K]]

[[Category: Venkatakrishnan, A J]]

[[Category: Wacker, D]]

[[Category: Wang, S]]

[[Category: Antagonist]]

[[Category: Dopamine receptor]]

[[Category: Gpcr]]

[[Category: Signaling protein-antagonist complex]]

[[Category: Sodium]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5wiu is ON HOLD  until Paper Publication
+==Structure of the human D4 Dopamine receptor in complex with Nemonapride==
+<StructureSection load='5wiu' size='340' side='right' caption='[[5wiu]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5wiu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WIU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WIU FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AQD:Nemonapride'>AQD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5wiv|5wiv]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wiu OCA], [http://pdbe.org/5wiu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wiu RCSB], [http://www.ebi.ac.uk/pdbsum/5wiu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wiu ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DRD4_HUMAN DRD4_HUMAN]] Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Betz, R M]]
+[[Category: Che, T]]
+[[Category: Dror, R O]]
+[[Category: Huang, X P]]
+[[Category: Levit, A]]
+[[Category: McCorvy, J D]]
+[[Category: Roth, B L]]
+[[Category: Shoichet, B K]]
+[[Category: Venkatakrishnan, A J]]
+[[Category: Wacker, D]]
+[[Category: Wang, S]]
+[[Category: Antagonist]]
+[[Category: Dopamine receptor]]
+[[Category: Gpcr]]
+[[Category: Signaling protein-antagonist complex]]
+[[Category: Sodium]]