5wjq: Difference between revisions

Revision as of 05:02, 8 March 2018

mouseZFP568-ZnF2-11 in complex with DNA

Structural highlights

5wjq is a 3 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	TRS, ZN
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ZN568_MOUSE] Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction (PubMed:22110054, PubMed:27658112). Essential during embryonic development, where it acts as direct repressor of IGF2-P0, placental-specific transcript of IGF2, in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers (PubMed:18701545, PubMed:22110054, PubMed:28522536). Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta (PubMed:18701545, PubMed:21094155). May enhance proliferation or maintenance of neural stem cells (PubMed:23071813).^[1] ^[2] ^[3] ^[4] ^[5]

References

↑ Garcia-Garcia MJ, Shibata M, Anderson KV. Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo. Development. 2008 Sep;135(18):3053-62. doi: 10.1242/dev.022897. Epub 2008 Aug 13. PMID:18701545 doi:https://dx.doi.org/10.1242/dev.022897
↑ Shibata M, Garcia-Garcia MJ. The mouse KRAB zinc-finger protein CHATO is required in embryonic-derived tissues to control yolk sac and placenta morphogenesis. Dev Biol. 2011 Jan 15;349(2):331-41. doi: 10.1016/j.ydbio.2010.11.015. Epub 2010 , Nov 19. PMID:21094155 doi:https://dx.doi.org/10.1016/j.ydbio.2010.11.015
↑ Shibata M, Blauvelt KE, Liem KF Jr, Garcia-Garcia MJ. TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra-embryonic tissues. Development. 2011 Dec;138(24):5333-43. doi: 10.1242/dev.072546. PMID:22110054 doi:https://dx.doi.org/10.1242/dev.072546
↑ Chien HC, Wang HY, Su YN, Lai KY, Lu LC, Chen PC, Tsai SF, Wu CI, Hsieh WS, Shen CK. Targeted disruption in mice of a neural stem cell-maintaining, KRAB-Zn finger-encoding gene that has rapidly evolved in the human lineage. PLoS One. 2012;7(10):e47481. doi: 10.1371/journal.pone.0047481. Epub 2012 Oct 10. PMID:23071813 doi:https://dx.doi.org/10.1371/journal.pone.0047481
↑ Murphy KE, Shylo NA, Alexander KA, Churchill AJ, Copperman C, Garcia-Garcia MJ. The Transcriptional Repressive Activity of KRAB Zinc Finger Proteins Does Not Correlate with Their Ability to Recruit TRIM28. PLoS One. 2016 Sep 22;11(9):e0163555. doi: 10.1371/journal.pone.0163555., eCollection 2016. PMID:27658112 doi:https://dx.doi.org/10.1371/journal.pone.0163555

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OCA

[1] Garcia-Garcia MJ, Shibata M, Anderson KV. Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo. Development. 2008 Sep;135(18):3053-62. doi: 10.1242/dev.022897. Epub 2008 Aug 13. PMID:18701545 doi:https://dx.doi.org/10.1242/dev.022897

[2] Shibata M, Garcia-Garcia MJ. The mouse KRAB zinc-finger protein CHATO is required in embryonic-derived tissues to control yolk sac and placenta morphogenesis. Dev Biol. 2011 Jan 15;349(2):331-41. doi: 10.1016/j.ydbio.2010.11.015. Epub 2010 , Nov 19. PMID:21094155 doi:https://dx.doi.org/10.1016/j.ydbio.2010.11.015

[3] Shibata M, Blauvelt KE, Liem KF Jr, Garcia-Garcia MJ. TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra-embryonic tissues. Development. 2011 Dec;138(24):5333-43. doi: 10.1242/dev.072546. PMID:22110054 doi:https://dx.doi.org/10.1242/dev.072546

[4] Chien HC, Wang HY, Su YN, Lai KY, Lu LC, Chen PC, Tsai SF, Wu CI, Hsieh WS, Shen CK. Targeted disruption in mice of a neural stem cell-maintaining, KRAB-Zn finger-encoding gene that has rapidly evolved in the human lineage. PLoS One. 2012;7(10):e47481. doi: 10.1371/journal.pone.0047481. Epub 2012 Oct 10. PMID:23071813 doi:https://dx.doi.org/10.1371/journal.pone.0047481

[5] Murphy KE, Shylo NA, Alexander KA, Churchill AJ, Copperman C, Garcia-Garcia MJ. The Transcriptional Repressive Activity of KRAB Zinc Finger Proteins Does Not Correlate with Their Ability to Recruit TRIM28. PLoS One. 2016 Sep 22;11(9):e0163555. doi: 10.1371/journal.pone.0163555., eCollection 2016. PMID:27658112 doi:https://dx.doi.org/10.1371/journal.pone.0163555

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5wjq is ON HOLD  until Paper Publication
+==mouseZFP568-ZnF2-11 in complex with DNA==
+<StructureSection load='5wjq' size='340' side='right' caption='[[5wjq]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
-Authors: Patel, A., Cheng, X.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5wjq]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WJQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WJQ FirstGlance]. <br>
-Description: mouseZFP568-ZnF2-11 in complex with DNA
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wjq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wjq OCA], [http://pdbe.org/5wjq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wjq RCSB], [http://www.ebi.ac.uk/pdbsum/5wjq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wjq ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ZN568_MOUSE ZN568_MOUSE]] Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction (PubMed:22110054, PubMed:27658112). Essential during embryonic development, where it acts as direct repressor of IGF2-P0, placental-specific transcript of IGF2, in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers (PubMed:18701545, PubMed:22110054, PubMed:28522536). Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta (PubMed:18701545, PubMed:21094155). May enhance proliferation or maintenance of neural stem cells (PubMed:23071813).<ref>PMID:18701545</ref> <ref>PMID:21094155</ref> <ref>PMID:22110054</ref> <ref>PMID:23071813</ref> <ref>PMID:27658112</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Cheng, X]]
 [[Category: Patel, A]]
+[[Category: C2h2 type zinc finger]]
+[[Category: Dna binding]]
+[[Category: Gene regulation]]
+[[Category: Gene regulation-dna complex]]
+[[Category: Transferase-dna complex]]

5wjq: Difference between revisions

Revision as of 05:02, 8 March 2018

mouseZFP568-ZnF2-11 in complex with DNA

Structural highlights

Function

References

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