5wmg: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5wmg is ~~ON HOLD until Paper Publication~~

==N-terminal bromodomain of BRD4 in complex with OTX-015==

~~Authors~~: ~~Zhang~~, Y.

== Structural highlights ==

<table><tr><td colspan='2'>[[5wmg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WMG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WMG FirstGlance]. <br>

~~Description~~: ~~N-terminal bromodomain of~~ BRD4 in ~~complex~~ with ~~OTX~~-~~015~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6JF:4-{6-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1S)-1-(pyridin-2-yl)ethyl]-1H-pyrrolo[3,2-b]pyridin-3-yl}benzoic+acid'>6JF</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wmg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wmg OCA], [http://pdbe.org/5wmg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wmg RCSB], [http://www.ebi.ac.uk/pdbsum/5wmg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wmg ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>

== Function ==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

== References ==

__TOC__

</StructureSection>

[[Category: Zhang, Y]]

[[Category: Brd4]]

[[Category: Bromodomain]]

[[Category: Plx51107]]

[[Category: Transcription]]

[[Category: Transcription-transcription inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5wmg is ON HOLD  until Paper Publication
+==N-terminal bromodomain of BRD4 in complex with OTX-015==
+<StructureSection load='5wmg' size='340' side='right' caption='[[5wmg]], [[Resolution|resolution]] 1.19&Aring;' scene=''>
-Authors: Zhang, Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5wmg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WMG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WMG FirstGlance]. <br>
-Description: N-terminal bromodomain of BRD4 in complex with OTX-015
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6JF:4-{6-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1S)-1-(pyridin-2-yl)ethyl]-1H-pyrrolo[3,2-b]pyridin-3-yl}benzoic+acid'>6JF</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wmg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wmg OCA], [http://pdbe.org/5wmg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wmg RCSB], [http://www.ebi.ac.uk/pdbsum/5wmg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wmg ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Zhang, Y]]
+[[Category: Brd4]]
+[[Category: Bromodomain]]
+[[Category: Plx51107]]
+[[Category: Transcription]]
+[[Category: Transcription-transcription inhibitor complex]]