5xof: Difference between revisions

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'''Unreleased structure'''


The entry 5xof is ON HOLD
==Crystal structure of human paired immunoglobulin-like type 2 receptor alpha with synthesized glycopeptide I==
 
<StructureSection load='5xof' size='340' side='right' caption='[[5xof]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
Authors: Furukawa, A., Kakita, K., Yamada, T., Ishizuka, M., Sakamoto, J., Hatori, N., Maeda, N., Ohsaka, F., Saitoh, T., Nomura, T., Kuroki, K., Nambu, H., Arase, H., Matsunaga, H., Anada, M., Ose, T., Hashimoto, S., Maenaka, K.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5xof]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XOF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XOF FirstGlance]. <br>
Description: Crystal structure of human paired immunoglobulin-like type 2 receptor alpha with synthesized glycopeptide I
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xof OCA], [http://pdbe.org/5xof PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xof RCSB], [http://www.ebi.ac.uk/pdbsum/5xof PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xof ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PILRA_HUMAN PILRA_HUMAN]] Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP.<ref>PMID:10903717</ref> <ref>PMID:18358807</ref> <ref>PMID:21241660</ref>  [[http://www.uniprot.org/uniprot/NOS3_HUMAN NOS3_HUMAN]] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.<ref>PMID:17264164</ref>  Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.<ref>PMID:17264164</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Anada, M]]
[[Category: Arase, H]]
[[Category: Furukawa, A]]
[[Category: Hashimoto, S]]
[[Category: Hatori, N]]
[[Category: Ishizuka, M]]
[[Category: Ishizuka, M]]
[[Category: Kakita, K]]
[[Category: Kakita, K]]
[[Category: Anada, M]]
[[Category: Kuroki, K]]
[[Category: Furukawa, A]]
[[Category: Maeda, N]]
[[Category: Maenaka, K]]
[[Category: Matsunaga, H]]
[[Category: Nambu, H]]
[[Category: Nomura, T]]
[[Category: Nomura, T]]
[[Category: Ohsaka, F]]
[[Category: Ohsaka, F]]
[[Category: Ose, T]]
[[Category: Saitoh, T]]
[[Category: Sakamoto, J]]
[[Category: Sakamoto, J]]
[[Category: Matsunaga, H]]
[[Category: Maeda, N]]
[[Category: Saitoh, T]]
[[Category: Kuroki, K]]
[[Category: Hashimoto, S]]
[[Category: Nambu, H]]
[[Category: Maenaka, K]]
[[Category: Yamada, T]]
[[Category: Yamada, T]]
[[Category: Ose, T]]
[[Category: Glycopeptide]]
[[Category: Arase, H]]
[[Category: Immune receptor]]
[[Category: Hatori, N]]
[[Category: Immune system]]
[[Category: Membrane protein]]
[[Category: Viral entry inhibitor]]
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