5xsg: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The entry ~~5xsg~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Ultrahigh resolution structure of FUS (37-42) SYSGYS determined by MicroED==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5xsg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XSG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XSG FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xsg OCA], [http://pdbe.org/5xsg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xsg RCSB], [http://www.ebi.ac.uk/pdbsum/5xsg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xsg ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/FUS_HUMAN FUS_HUMAN]] Frontotemporal dementia with motor neuron disease;Hereditary essential tremor;Amyotrophic lateral sclerosis;Juvenile amyotrophic lateral sclerosis;Myxofibrosarcoma;Myxoid/round cell liposarcoma. A chromosomal aberration involving FUS is found in a patient with malignant myxoid liposarcoma. Translocation t(12;16)(q13;p11) with DDIT3. A chromosomal aberration involving FUS is a cause of acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with ERG. The disease may be caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving FUS is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with ATF1 generates a chimeric FUS/ATF1 protein. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[[http://www.uniprot.org/uniprot/FUS_HUMAN FUS_HUMAN]] Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.

__TOC__

</StructureSection>

[[Category: Gui, X]]

[[Category: Li, D]]

[[Category: Li, X]]

[[Category: Liu, C]]

[[Category: Luo, F]]

[[Category: Zhou, H]]

[[Category: Cross-coil amyloid fibril]]

[[Category: Fus low complexity domain]]

[[Category: Reversible amyloid fibril]]

[[Category: Rna binding protein]]

[[Category: Rna granule assembly]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5xsg is ON HOLD  until Paper Publication
+==Ultrahigh resolution structure of FUS (37-42) SYSGYS determined by MicroED==
+<StructureSection load='5xsg' size='340' side='right' caption='[[5xsg]], [[Resolution|resolution]] 0.73&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5xsg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XSG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XSG FirstGlance]. <br>
-Description:
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xsg OCA], [http://pdbe.org/5xsg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xsg RCSB], [http://www.ebi.ac.uk/pdbsum/5xsg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xsg ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/FUS_HUMAN FUS_HUMAN]] Frontotemporal dementia with motor neuron disease;Hereditary essential tremor;Amyotrophic lateral sclerosis;Juvenile amyotrophic lateral sclerosis;Myxofibrosarcoma;Myxoid/round cell liposarcoma. A chromosomal aberration involving FUS is found in a patient with malignant myxoid liposarcoma. Translocation t(12;16)(q13;p11) with DDIT3.  A chromosomal aberration involving FUS is a cause of acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with ERG.  The disease may be caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving FUS is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with ATF1 generates a chimeric FUS/ATF1 protein.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/FUS_HUMAN FUS_HUMAN]] Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.
+__TOC__
+</StructureSection>
+[[Category: Gui, X]]
+[[Category: Li, D]]
+[[Category: Li, X]]
+[[Category: Liu, C]]
+[[Category: Luo, F]]
+[[Category: Zhou, H]]
+[[Category: Cross-coil amyloid fibril]]
+[[Category: Fus low complexity domain]]
+[[Category: Reversible amyloid fibril]]
+[[Category: Rna binding protein]]
+[[Category: Rna granule assembly]]