5xv3: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5xv3 is ~~ON HOLD until Paper Publication~~

==Crystal structure of ATG101-ATG13HORMA==

~~Authors~~: ~~Kim~~, B.-W., ~~Song~~, H.K.

== Structural highlights ==

<table><tr><td colspan='2'>[[5xv3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XV3 FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of ~~ATG101~~-~~ATG13HORMA~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xv3 OCA], [http://pdbe.org/5xv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xv3 RCSB], [http://www.ebi.ac.uk/pdbsum/5xv3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xv3 ProSAT]</span></td></tr>

[[Category: Kim, B.-W]]

</table>

[[Category: Song, H.K]]

== Function ==

[[http://www.uniprot.org/uniprot/ATG13_HUMAN ATG13_HUMAN]] Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.<ref>PMID:19287211</ref> <ref>PMID:19211835</ref> <ref>PMID:19225151</ref> <ref>PMID:21855797</ref> <ref>PMID:18936157</ref> <ref>PMID:21795849</ref> [[http://www.uniprot.org/uniprot/ATGA1_HUMAN ATGA1_HUMAN]] Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.<ref>PMID:19287211</ref> <ref>PMID:19597335</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Kim, B W]]

[[Category: Song, H K]]

[[Category: Atg101]]

[[Category: Atg13]]

[[Category: Autophagy]]

[[Category: Horma]]

[[Category: Protein binding]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5xv3 is ON HOLD  until Paper Publication
+==Crystal structure of ATG101-ATG13HORMA==
+<StructureSection load='5xv3' size='340' side='right' caption='[[5xv3]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
-Authors: Kim, B.-W., Song, H.K.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5xv3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XV3 FirstGlance]. <br>
-Description: Crystal structure of ATG101-ATG13HORMA
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xv3 OCA], [http://pdbe.org/5xv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xv3 RCSB], [http://www.ebi.ac.uk/pdbsum/5xv3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xv3 ProSAT]</span></td></tr>
-[[Category: Kim, B.-W]]
+</table>
-[[Category: Song, H.K]]
+== Function ==
+[[http://www.uniprot.org/uniprot/ATG13_HUMAN ATG13_HUMAN]] Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.<ref>PMID:19287211</ref> <ref>PMID:19211835</ref> <ref>PMID:19225151</ref> <ref>PMID:21855797</ref> <ref>PMID:18936157</ref> <ref>PMID:21795849</ref>  [[http://www.uniprot.org/uniprot/ATGA1_HUMAN ATGA1_HUMAN]] Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.<ref>PMID:19287211</ref> <ref>PMID:19597335</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Kim, B W]]
+[[Category: Song, H K]]
+[[Category: Atg101]]
+[[Category: Atg13]]
+[[Category: Autophagy]]
+[[Category: Horma]]
+[[Category: Protein binding]]