5xwr: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5xwr is ~~ON HOLD~~ ~~until Paper Publication~~

==Crystal Structure of RBBP4-peptide complex==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5xwr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XWR FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xwr OCA], [http://pdbe.org/5xwr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xwr RCSB], [http://www.ebi.ac.uk/pdbsum/5xwr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xwr ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/RBBP4_HUMAN RBBP4_HUMAN]] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.<ref>PMID:10866654</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Daniel, G T]]

[[Category: Jobichen, C]]

[[Category: Lui, B H]]

[[Category: Sivaraman, J]]

[[Category: Histone binding protein]]

[[Category: Sall4]]

[[Category: Transcription]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5xwr is ON HOLD  until Paper Publication
+==Crystal Structure of RBBP4-peptide complex==
+<StructureSection load='5xwr' size='340' side='right' caption='[[5xwr]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5xwr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XWR FirstGlance]. <br>
-Description:
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xwr OCA], [http://pdbe.org/5xwr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xwr RCSB], [http://www.ebi.ac.uk/pdbsum/5xwr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xwr ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/RBBP4_HUMAN RBBP4_HUMAN]] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.<ref>PMID:10866654</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Daniel, G T]]
+[[Category: Jobichen, C]]
+[[Category: Lui, B H]]
+[[Category: Sivaraman, J]]
+[[Category: Histone binding protein]]
+[[Category: Sall4]]
+[[Category: Transcription]]