5xxi: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "5xxi" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal structure of CYP2C9 in complex with multiple losartan molecules== | |||
<StructureSection load='5xxi' size='340' side='right' caption='[[5xxi]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5xxi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XXI FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LSN:[2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol'>LSN</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xxi OCA], [http://pdbe.org/5xxi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xxi RCSB], [http://www.ebi.ac.uk/pdbsum/5xxi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xxi ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CP2C9_HUMAN CP2C9_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Adachi, M]] | |||
[[Category: Maekawa, K]] | |||
[[Category: Shah, M B]] | |||
[[Category: Cyp2c9]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: P450 2c9]] | |||
Revision as of 07:19, 25 October 2017
Crystal structure of CYP2C9 in complex with multiple losartan molecules
| ||||||||||||
