5y1u: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5y1u is ~~ON HOLD until Paper Publication~~

==Crystal structure of RBBP4 bound to AEBP2 RRK motif==

~~Authors~~: ~~Sun~~, A., Li, F., Wu, J.~~, Shi, Y~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[5y1u]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y1U FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of ~~RBBP4 bound to AEBP2 RRK motif~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y1u OCA], [http://pdbe.org/5y1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y1u RCSB], [http://www.ebi.ac.uk/pdbsum/5y1u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y1u ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/RBBP4_HUMAN RBBP4_HUMAN]] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.<ref>PMID:10866654</ref> [[http://www.uniprot.org/uniprot/AEBP2_HUMAN AEBP2_HUMAN]] DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3.<ref>PMID:15225548</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Li, F]]

[[Category: Shi, Y]]

[[Category: Sun, A]]

~~[[Category: Shi, Y]]~~

[[Category: Wu, J]]

[[Category: Aebp2]]

[[Category: Gene regulation]]

[[Category: Rbap48]]

[[Category: Rbbp4]]

[[Category: Wd40]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5y1u is ON HOLD  until Paper Publication
+==Crystal structure of RBBP4 bound to AEBP2 RRK motif==
+<StructureSection load='5y1u' size='340' side='right' caption='[[5y1u]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
-Authors: Sun, A., Li, F., Wu, J., Shi, Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5y1u]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y1U FirstGlance]. <br>
-Description: Crystal structure of RBBP4 bound to AEBP2 RRK motif
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y1u OCA], [http://pdbe.org/5y1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y1u RCSB], [http://www.ebi.ac.uk/pdbsum/5y1u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y1u ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/RBBP4_HUMAN RBBP4_HUMAN]] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.<ref>PMID:10866654</ref>  [[http://www.uniprot.org/uniprot/AEBP2_HUMAN AEBP2_HUMAN]] DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3.<ref>PMID:15225548</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Li, F]]
+[[Category: Shi, Y]]
 [[Category: Sun, A]]
-[[Category: Shi, Y]]
 [[Category: Wu, J]]
+[[Category: Aebp2]]
+[[Category: Gene regulation]]
+[[Category: Rbap48]]
+[[Category: Rbbp4]]
+[[Category: Wd40]]