5y80: Difference between revisions
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==Complex structure of cyclin G-associated kinase with gefitinib== | |||
<StructureSection load='5y80' size='340' side='right' caption='[[5y80]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5y80]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y80 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y80 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IRE:GEFITINIB'>IRE</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y80 OCA], [http://pdbe.org/5y80 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y80 RCSB], [http://www.ebi.ac.uk/pdbsum/5y80 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y80 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/GAK_HUMAN GAK_HUMAN]] Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.<ref>PMID:10625686</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Non-specific serine/threonine protein kinase]] | |||
[[Category: Kato-Murayama, M]] | |||
[[Category: Murayama, K]] | |||
[[Category: Ohbayashi, N]] | |||
[[Category: Shirouzu, M]] | |||
[[Category: Complex]] | |||
[[Category: Kinase]] | |||
[[Category: Transferase-immune system complex]] | |||
Revision as of 07:18, 29 August 2018
Complex structure of cyclin G-associated kinase with gefitinib
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