5y9j: Difference between revisions
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==BAFF in complex with belimumab== | |||
<StructureSection load='5y9j' size='340' side='right' caption='[[5y9j]], [[Resolution|resolution]] 2.05Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5y9j]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y9J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y9J FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y9j OCA], [http://pdbe.org/5y9j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y9j RCSB], [http://www.ebi.ac.uk/pdbsum/5y9j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y9j ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/TN13B_HUMAN TN13B_HUMAN]] Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.<ref>PMID:10973284</ref> Isoform 2 seems to inhibit isoform 1 secretion and bioactivity (By similarity).<ref>PMID:10973284</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Heo, Y S]] | |||
[[Category: Shin, W]] | |||
[[Category: Antibody]] | |||
[[Category: Baff]] | |||
[[Category: Belimumab]] | |||
[[Category: Lupus]] | |||
[[Category: Protein binding]] | |||
