6atw: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6atw is ~~ON HOLD until Paper Publication~~

==Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox==

~~Authors~~: ~~Gewe~~, M.M., ~~Rupert~~, P., ~~Strong~~, R.K.

== Structural highlights ==

<table><tr><td colspan='2'>[[6atw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ATW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ATW FirstGlance]. <br>

~~Description: Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6atw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6atw OCA], [http://pdbe.org/6atw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6atw RCSB], [http://www.ebi.ac.uk/pdbsum/6atw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6atw ProSAT]</span></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

</table>

~~[[Category~~: ~~Strong~~, R.~~K]]~~

== Function ==

[[Category: Gewe, M.M]]

[[http://www.uniprot.org/uniprot/CTXL_LEIQU CTXL_LEIQU]] This toxin binds to the surface of glioma cells, and inhibits their proliferation without having effects on normal brain cells. In this context, this toxin has been described as a chloride channel inhibitor (probably ClC-3/CLCN3) by causing its internalization via caveolae (PubMed:16520829). It has also been described to selectively interact with MMP2 (in complex with MT1-MMP (MMP14) and TIMP2), to inhibit its enzymatic activity and to decrease its presence at the cell surface (PubMed:12454020).<ref>PMID:12454020</ref> <ref>PMID:16520829</ref> <ref>PMID:8383429</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Gewe, M M]]

[[Category: Rupert, P]]

[[Category: Strong, R K]]

[[Category: Cystine knot]]

[[Category: Knottin]]

[[Category: Toxin]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6atw is ON HOLD  until Paper Publication
+==Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox==
+<StructureSection load='6atw' size='340' side='right' caption='[[6atw]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
-Authors: Gewe, M.M., Rupert, P., Strong, R.K.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6atw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ATW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ATW FirstGlance]. <br>
-Description: Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6atw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6atw OCA], [http://pdbe.org/6atw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6atw RCSB], [http://www.ebi.ac.uk/pdbsum/6atw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6atw ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Strong, R.K]]
+== Function ==
-[[Category: Gewe, M.M]]
+[[http://www.uniprot.org/uniprot/CTXL_LEIQU CTXL_LEIQU]] This toxin binds to the surface of glioma cells, and inhibits their proliferation without having effects on normal brain cells. In this context, this toxin has been described as a chloride channel inhibitor (probably ClC-3/CLCN3) by causing its internalization via caveolae (PubMed:16520829). It has also been described to selectively interact with MMP2 (in complex with MT1-MMP (MMP14) and TIMP2), to inhibit its enzymatic activity and to decrease its presence at the cell surface (PubMed:12454020).<ref>PMID:12454020</ref> <ref>PMID:16520829</ref> <ref>PMID:8383429</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Gewe, M M]]
 [[Category: Rupert, P]]
+[[Category: Strong, R K]]
+[[Category: Cystine knot]]
+[[Category: Knottin]]
+[[Category: Toxin]]