6ayk: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6ayk is ~~ON HOLD until Paper Publication~~

==Crystal structure of TEM1 beta-lactamase mutant I263A in the presence of 1.2 MPa xenon==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6ayk]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AYK OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AYK FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=XE:XENON'>XE</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ayk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ayk OCA], [http://pdbe.org/6ayk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ayk RCSB], [http://www.ebi.ac.uk/pdbsum/6ayk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ayk ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX]] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.

__TOC__

</StructureSection>

[[Category: Beta-lactamase]]

[[Category: Dmochowski, I J]]

[[Category: Roose, B W]]

[[Category: Enzyme]]

[[Category: Hydrolase]]

[[Category: Xenon]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6ayk is ON HOLD  until Paper Publication
+==Crystal structure of TEM1 beta-lactamase mutant I263A in the presence of 1.2 MPa xenon==
+<StructureSection load='6ayk' size='340' side='right' caption='[[6ayk]], [[Resolution|resolution]] 1.44&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ayk]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AYK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AYK FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XE:XENON'>XE</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ayk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ayk OCA], [http://pdbe.org/6ayk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ayk RCSB], [http://www.ebi.ac.uk/pdbsum/6ayk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ayk ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX]] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
+__TOC__
+</StructureSection>
+[[Category: Beta-lactamase]]
+[[Category: Dmochowski, I J]]
+[[Category: Roose, B W]]
+[[Category: Enzyme]]
+[[Category: Hydrolase]]
+[[Category: Xenon]]