6ein: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 6ein is ON HOLD  until Mar 19 2019
==Crystal structure of KDM5B in complex with S49365a.==
 
<StructureSection load='6ein' size='340' side='right' caption='[[6ein]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
Authors: Srikannathasan, V., Newman, J.A., Szykowska, A., Wright, M., Ruda, G.F., Vazquez-Rodriguez, S.A., Kupinska, K., Strain-Damerell, C., Burgess-Brown, N.A., Arrowsmith, C.H., Edwards, A., Bountra, C., Oppermann, U., Huber, K., von Delft, F.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6ein]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EIN FirstGlance]. <br>
Description: Crystal structure of KDM5B in complex with S49365a.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B7Z:8-[4-[2-[4-(3-oxidanylpropanoyl)piperazin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one'>B7Z</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ein FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ein OCA], [http://pdbe.org/6ein PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ein RCSB], [http://www.ebi.ac.uk/pdbsum/6ein PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ein ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Burgess-Brown, N A]]
[[Category: Delft, F von]]
[[Category: Edwards, A]]
[[Category: Huber, K]]
[[Category: Huber, K]]
[[Category: Ruda, G.F]]
[[Category: Kupinska, K]]
[[Category: Arrowsmith, C.H]]
[[Category: Newman, J A]]
[[Category: Oppermann, U]]
[[Category: Oppermann, U]]
[[Category: Ruda, G F]]
[[Category: Srikannathasan, V]]
[[Category: Strain-Damerell, C]]
[[Category: Szykowska, A]]
[[Category: Szykowska, A]]
[[Category: Burgess-Brown, N.A]]
[[Category: Vazquez-Rodriguez, S A]]
[[Category: Von Delft, F]]
[[Category: Vazquez-Rodriguez, S.A]]
[[Category: Newman, J.A]]
[[Category: Edwards, A]]
[[Category: Strain-Damerell, C]]
[[Category: Wright, M]]
[[Category: Wright, M]]
[[Category: Srikannathasan, V]]
[[Category: Kdm5b lysine specific demethylase]]
[[Category: Bountra, C]]
[[Category: Oxidoreductase]]
[[Category: Kupinska, K]]
Retrieved from "https://proteopedia.org/6ein"