6ejx: Difference between revisions
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==The metal ion-dependent adhesion site (MIDAS) of the alphaMbeta2 integrin Mac-1 I-domain promiscuously and competitively binds multiple ligands in the regulation of Leukocyte function== | |||
<StructureSection load='6ejx' size='340' side='right' caption='[[6ejx]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ejx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EJX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EJX FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=POL:N-PROPANOL'>POL</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ejx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ejx OCA], [http://pdbe.org/6ejx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ejx RCSB], [http://www.ebi.ac.uk/pdbsum/6ejx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ejx ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/GP1BA_MOUSE GP1BA_MOUSE]] GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Emsley, J]] | |||
[[Category: Saleem, M]] | [[Category: Saleem, M]] | ||
[[Category: | [[Category: Blood clotting]] | ||
[[Category: Gp1balpha]] | |||
[[Category: Mac-1]] | |||
Revision as of 05:54, 24 October 2018
The metal ion-dependent adhesion site (MIDAS) of the alphaMbeta2 integrin Mac-1 I-domain promiscuously and competitively binds multiple ligands in the regulation of Leukocyte function
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