1y6m: Difference between revisions

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[[Image:1y6m.gif|left|200px]]
[[Image:1y6m.gif|left|200px]]


{{Structure
<!--
|PDB= 1y6m |SIZE=350|CAPTION= <scene name='initialview01'>1y6m</scene>, resolution 2.8&Aring;
The line below this paragraph, containing "STRUCTURE_1y6m", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
|LIGAND=
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY=
or leave the SCENE parameter empty for the default display.
|GENE= BCRF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10376 Human herpesvirus 4]), IL10RA, IL10R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
-->
|DOMAIN=
{{STRUCTURE_1y6m|  PDB=1y6m |  SCENE= }}  
|RELATEDENTRY=[[1y6k|1Y6K]], [[1j7v|1J7V]], [[1y6n|1Y6N]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y6m OCA], [http://www.ebi.ac.uk/pdbsum/1y6m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1y6m RCSB]</span>
}}


'''Crystal structure of Epstein-Barr virus IL-10 complexed with the soluble IL-10R1 chain'''
'''Crystal structure of Epstein-Barr virus IL-10 complexed with the soluble IL-10R1 chain'''
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[[Category: Walter, M R.]]
[[Category: Walter, M R.]]
[[Category: Yoon, S I.]]
[[Category: Yoon, S I.]]
[[Category: helix bundle]]
[[Category: Helix bundle]]
[[Category: receptor complex]]
[[Category: Receptor complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:55:57 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:59:26 2008''

Revision as of 12:55, 3 May 2008

File:1y6m.gif

Template:STRUCTURE 1y6m

Crystal structure of Epstein-Barr virus IL-10 complexed with the soluble IL-10R1 chain


Overview

Human IL-10 (hIL-10) is a cytokine that modulates diverse immune responses. The Epstein-Barr virus (EBV) genome contains an IL-10 homolog (vIL-10) that shares high sequence and structural similarity with hIL-10. Although vIL-10 suppresses inflammatory responses like hIL-10, it cannot activate many other immunostimulatory functions performed by the cellular cytokine. These functional differences have been correlated with the approximately 1000-fold lower affinity of vIL-10, compared to hIL-10, for the IL-10R1 receptor chain. To define the structural basis for these observations, crystal structures of vIL-10 and a vIL-10 point mutant were determined bound to the soluble IL-10R1 receptor fragment (sIL-10R1) at 2.8 and 2.7 A resolution, respectively. The structures reveal that subtle changes in the conformation and dynamics of the vIL-10 AB and CD loops and an orientation change of vIL-10 on sIL-10R1 are the main factors responsible for vIL-10's reduced affinity for sIL-10R1 and its distinct biological profile.

About this Structure

1Y6M is a Protein complex structure of sequences from Homo sapiens and Human herpesvirus 4. Full crystallographic information is available from OCA.

Reference

Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain., Yoon SI, Jones BC, Logsdon NJ, Walter MR, Structure. 2005 Apr;13(4):551-64. PMID:15837194 Page seeded by OCA on Sat May 3 15:55:57 2008

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