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Line 24: |
| *Di-or tripeptide:H+ symporter | | *Di-or tripeptide:H+ symporter |
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| **[[4ja4]], [[4xni]], [[4xnj]], [[4d2b]], [[4aps]], [[5d6k]] – StSymp – ''Streptococcus thermophilus''<BR /> | | **[[4ja4]], [[4xni]], [[4xnj]], [[4d2b]], [[4aps]], [[5d6k]], [[5mmt]] – StSymp – ''Streptococcus thermophilus''<BR /> |
| **[[4d2d]] – StSymp + tripeptide<BR /> | | **[[4d2d]] – StSymp + tripeptide<BR /> |
| **[[4d2c]], [[5d58]], [[5d59]] – StSymp + dipeptide<BR /> | | **[[4d2c]], [[5d58]], [[5d59]] – StSymp + dipeptide<BR /> |
| Line 51: |
Line 51: |
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| **[[5a1s]] – Symp + citrate – ''Salmonella enterica''<BR /> | | **[[5a1s]] – Symp + citrate – ''Salmonella enterica''<BR /> |
| | **[[5x9r]], [[5xas]], [[5xat]] – KpSymp + citrate – ''Klebsiella pneumoniae''<BR /> |
| | **[[5xar]] – KpSymp <BR /> |
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| | *Divalent ion/sodium symporter |
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| | **[[5ul7]], [[5ul9]], [[5uld]], [[5ule]] – Symp + Na – ''Vibrio cholerae''<BR /> |
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| *Purine/H+ symporter | | *Purine/H+ symporter |
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| **[[5i6c]] – Symp + xanthine – ''Aspergillus nidulans''<BR /> | | **[[5i6c]] – Symp + xanthine – ''Aspergillus nidulans''<BR /> |
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| | *Glutamate/H+ symporter |
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| | **[[5dwy]] – TkSymp – ''Thermococcus kodakarensis''<BR /> |
| | **[[5e9s]] – TkSymp + aspartate<BR /> |
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| }} | | }} |
| Function
Symporter (Symp) is a co-transporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction[1].
Disease
Mutations in sodium/iodide symporter cause iodide transport defects[2].
Structural highlights
Dipeptide:H symporter binds the dipeptide between its N- and C-terminal bundles[3].
- ↑ Dohan O, De la Vieja A, Paroder V, Riedel C, Artani M, Reed M, Ginter CS, Carrasco N. The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance. Endocr Rev. 2003 Feb;24(1):48-77. PMID:12588808 doi:https://dx.doi.org/10.1210/er.2001-0029
- ↑ Pohlenz J, Refetoff S. Mutations in the sodium/iodide symporter (NIS) gene as a cause for iodide transport defects and congenital hypothyroidism. Biochimie. 1999 May;81(5):469-76. PMID:10403177
- ↑ Lyons JA, Parker JL, Solcan N, Brinth A, Li D, Shah ST, Caffrey M, Newstead S. Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters. EMBO Rep. 2014 Jun 10. pii: e201338403. PMID:24916388 doi:https://dx.doi.org/10.15252/embr.201338403
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3D Structures of symporter
Updated on 06-October-2017
{"openlevels":0}
- D-xylose/H+ symporter
- 4ja4, 4qiq – EcSymp – Escherichia coli
- 4ja3 – EcSymp (mutant)
- 4gby – EcSymp + xylose
- 4gbz, 4gc0 – EcSymp + glucose derivative
- Di-or tripeptide:H+ symporter
- Oligopeptide/H+ symporter
- Sodium/bile acid symporter
- 4n7w – YfSymp – Yersinia frederiksenii
- 4n7x – YfSymp (mutant)
- L-fucose/H+ symporter
- Sodium/glucose symporter
- 2xq2 – VpSymp (mutant) – Vibrio parahaemolyticus
- 3dh4 – VpSymp + galactose
- Sodium/citrate symporter
- 5a1s – Symp + citrate – Salmonella enterica
- 5x9r, 5xas, 5xat – KpSymp + citrate – Klebsiella pneumoniae
- 5xar – KpSymp
- Divalent ion/sodium symporter
- Purine/H+ symporter
- 5i6c – Symp + xanthine – Aspergillus nidulans
- Glutamate/H+ symporter
- 5dwy – TkSymp – Thermococcus kodakarensis
- 5e9s – TkSymp + aspartate
References
