5oxj: Difference between revisions

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'''Unreleased structure'''


The entry 5oxj is ON HOLD  until Paper Publication
==Crystal structure of KlenTaq mutant M747K in a closed ternary complex with a O6-MeG:BenziTP base pair==
<StructureSection load='5oxj' size='340' side='right' caption='[[5oxj]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5oxj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OXJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NZI:[(2~{R},3~{S},5~{R})-3-oxidanyl-5-(2-oxidanylidene-3~{H}-benzimidazol-1-yl)oxolan-2-yl]methyl+[oxidanyl(phosphonooxy)phosphoryl]+hydrogen+phosphate'>NZI</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OG:6-O-METHYL+GUANOSINE-5-MONOPHOSPHATE'>6OG</scene>, <scene name='pdbligand=DDG:2,3-DIDEOXY-GUANOSINE-5-MONOPHOSPHATE'>DDG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oxj OCA], [http://pdbe.org/5oxj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oxj RCSB], [http://www.ebi.ac.uk/pdbsum/5oxj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oxj ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The possibility to sequence cytotoxic O(6)-alkylG DNA adducts would greatly benefit research. Recently we reported a benzimidazole-derived nucleotide that is selectively incorporated opposite the damaged site by a mutated DNA polymerase. Here we provide the structural basis for this reaction which may spur future developments in DNA damage sequencing.


Authors: Betz, K., Diederichs, K., Marx, A.
Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase.,Betz K, Nilforoushan A, Wyss LA, Diederichs K, Sturla SJ, Marx A Chem Commun (Camb). 2017 Nov 23;53(94):12704-12707. doi: 10.1039/c7cc07173f. PMID:29136072<ref>PMID:29136072</ref>


Description: Crystal structure of KlenTaq mutant M747K in a closed ternary complex with a O6-MeG:BenziTP base pair
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 5oxj" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: DNA-directed DNA polymerase]]
[[Category: Betz, K]]
[[Category: Diederichs, K]]
[[Category: Diederichs, K]]
[[Category: Betz, K]]
[[Category: Marx, A]]
[[Category: Marx, A]]
[[Category: Dna polymerase]]
[[Category: Transferase]]
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