6apg: Difference between revisions

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'''Unreleased structure'''


The entry 6apg is ON HOLD  until Paper Publication
==Trans-acting transferase from Disorazole synthase with malonate==
<StructureSection load='6apg' size='340' side='right' caption='[[6apg]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6apg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6APG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6APG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6apg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6apg OCA], [http://pdbe.org/6apg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6apg RCSB], [http://www.ebi.ac.uk/pdbsum/6apg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6apg ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of the trans-acyltransferase (AT) from the disorazole polyketide synthase (PKS) was determined at room temperature to a resolution of 2.5 A using a new method for the direct delivery of the sample into an X-ray free-electron laser. A novel sample extractor efficiently delivered limited quantities of microcrystals directly from the native crystallization solution into the X-ray beam at room temperature. The AT structure revealed important catalytic features of this core PKS enzyme, including the occurrence of conformational changes around the active site. The implications of these conformational changes for polyketide synthase reaction dynamics are discussed.


Authors: Mathews, I.I., Lyubimov, A.Y., Soltis, S.M., Khosla, C., Robbins, T., Cohen, A.E.
The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography.,Mathews II, Allison K, Robbins T, Lyubimov AY, Uervirojnangkoorn M, Brunger AT, Khosla C, DeMirci H, McPhillips SE, Hollenbeck M, Soltis M, Cohen AE Biochemistry. 2017 Sep 12;56(36):4751-4756. doi: 10.1021/acs.biochem.7b00711., Epub 2017 Aug 31. PMID:28832129<ref>PMID:28832129</ref>


Description: Trans-acting transferase from Disorazole synthase with malonate
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 6apg" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Cohen, A E]]
[[Category: Khosla, C]]
[[Category: Lyubimov, A Y]]
[[Category: Mathews, I I]]
[[Category: Robbins, T]]
[[Category: Robbins, T]]
[[Category: Cohen, A.E]]
[[Category: Soltis, S M]]
[[Category: Lyubimov, A.Y]]
[[Category: Acyl transferase]]
[[Category: Mathews, I.I]]
[[Category: Disorazole synthase]]
[[Category: Soltis, S.M]]
[[Category: Malonate complex]]
[[Category: Khosla, C]]
[[Category: Polyketide synthase]]
[[Category: Transferase]]
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